ArticleNeurocritical care2024
The Origin of the Burst-Suppression Paradigm in Treatment of Status Epilepticus.
Article in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Assessment of therapeutic management practices in generalized and focal motor status epilepticus: An international survey in French, Belgian, and Swiss intensive care units.Journal of intensive medicine · 2026Article
- An extreme type of new onset refractory status epilepticus with stimulus-induced seizures in pharmacological isoelectric states.Epilepsia · 2026Article
- Overreliance on EEG normalization: a case report of DEE-SWAS treated as presumed NCSE leading to avoidable escalation.Frontiers in pediatrics · 2026Article
- Diagnosis, treatment, and outcome prediction of non-convulsive status epilepticus in unconscious patients in intensive care units.Neurological research and practice · 2025Review
- Burst Suppression as a Treatment Goal in Refractory Status Epilepticus.Neurocritical care · 2024Article
- Anesthetics in status epilepticus: does one size fits it all?-A scoping review on titration goals, timing, and patient selection.Frontiers in neurologyReview
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After electroencephalography (EEG) was introduced in hospitals, early literature recognized burst-suppression pattern (BSP) as a distinctive EEG pattern characterized by intermittent high-power oscillations alternating with isoelectric periods in coma and epileptic encephalopathies of childhood or the pattern could be induced by general anesthesia and hypothermia. The term was introduced by Swank and Watson in 1949 but was initially described by Derbyshire et al. in 1936 in their study about the anesthetic effects of tribromoethanol. Once the EEG/BSP pattern emerged in the literature as therapeutic goal in refractory status epilepticus, researchers began exploring whether the depth of EEG suppression correlated with improved seizure control and clinical outcomes. We can conclude that, from a historical perspective, the evidence to suppress the brain to a BSP when treating status epilepticus is inconclusive.
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Registered trials
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