SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2024
Distraction osteogenesis versus induced membrane technique for infected tibial non-unions with segmental bone loss: a systematic review of the literature and meta-analysis of available studies.
Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Cumulative operative burden is associated with poorer function after segmental bone transport for lower-extremity long-bone defects.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- The Use of Osteo-Inductive 3D-Printed Scaffolds Covered with a Pleiotrophin Peptide for Bone Defects: An In Vivo Experimental Study.Bioengineering (Basel, Switzerland) · 2026Article
- Evolution of the ilizarov technique: A scoping review of improvement.Langenbeck's archives of surgery · 2026Article
- Custom 3D implants for managing bone defects-indications and lessons learned.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Review
- Management and Treatment Strategies for Distal Tibia and Ankle Infections: Our Clinical Experience.Journal of clinical medicine · 2025Article
- Treatment of Post-Traumatic Diaphyseal and Distal Tibial Bone Defects by Distraction Osteogenesis: A Monocentric Experience.Journal of clinical medicine · 2025Article
- Basic science and current management for fracture-related infections.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Article
- The "Bone Block Technique": Reconstruction of Bone Defects Caused by Osteomyelitis Using Corticocancellous Bone Blocks from the Iliac Crest and the Induced Membrane Technique.Life (Basel, Switzerland) · 2025Article
- Effectiveness of the induced membrane technique in aseptic and infected long-bone defect management: Are there any differences?World journal of orthopedics · 2025Review
- Cable-asisted bone transport versus circular external fixators-asisted bone transport in the management of bone defects of the Tibia: clinical and imaging results.Journal of orthopaedic surgery and research · 2025Article
- Custom-Made 3D-Printed Titanium Implants for Managing Segmental Distal Tibial Bone Defects: A Systematic Literature Review.Journal of clinical medicine · 2025Review
- Introducing the Pearl-String Technique: A New Concept in the Treatment of Large Bone Defects.Life (Basel, Switzerland) · 2025Article
- Masquelet technique including a multiperforated non-vascularized fibula graft for the reconstruction of massive post-traumatic bone defects in military practice.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Outcomes of Infected Non-unions of Distal Femur Managed with the Masquelet Method and Ilizarov Ring Fixator.Indian journal of orthopaedics · 2024Article
- Management of Infected Tibial Nonunion: Combining Synthetic Bone Grafting with Continuous Local Antibiotic Perfusion (CLAP).The American journal of case reports · 2024Article
- A case series utilizing bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma and autologous fibrin for the treatment of femur nonunions.Regenerative medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfected tibial non-unions with associated bone loss can be challenging to manage. At present, the two main methods utilized in the management of these fractures include the Ilizarov technique of Distraction Osteogenesis (DO) using external fixator devices, or alternatively, the Induced Membrane Technique (IMT), devised by Masquelet. As there is a paucity of data directly comparing the outcomes of these techniques, there is no universal agreement on which strategy a surgeon should choose to use.
aimsThis systematic review and meta-analysis aimed to summarize the outcomes of both DO and IMT, in terms of primary outcomes (bone union and infection elimination), and secondary outcomes (complication rates and functional outcomes).
methodsA PRISMA strategy was used. Medline, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar library databases were interrogated using pre-defined MeSH terms and Boolean operators. Quality of evidence was evaluated using OCEBM and GRADE systems.
resultsThirty-two studies with 1136 subjects met the inclusion criteria. With respect to the primary outcomes of interest, union was observed in 94.6% (DO method) and 88.0% (IMT method); this difference, however, was not significant between the two techniques (p = 0.45). In addition, infection elimination rates were also higher in the Ilizarov DO group when compared to Masquelet (Mq) IMT (93.0% vs 80.4% respectively). Again, no significant difference was observed (p = 0.06). For all secondary outcomes assessed (unplanned re-operations, re-fracture rates amputation rate), no statistically significant differences were documented between the treatment options.
conclusionThis study demonstrated that there is no clinical difference in outcomes for patients treated with Ilizarov DO versus Mq IMT techniques. The evidence base at present is relatively sparse and, therefore, we would recommend for further Level I studies to be conducted, to make more meaningful conclusions.
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