Evidence map›Paper›PMID 37921621›Full record

ArticleJournal of veterinary internal medicine

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats.

Marios Charalambous, Karen Muñana, Edward E Patterson, Simon R Platt, Holger A Volk

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Glaucoma in a Siberian Tiger (Animals : an open access journal from MDPI · 2026
    Article
  6. Single-Dose Pharmacokinetics of Intranasal Levetiracetam in Healthy Dogs.Journal of veterinary pharmacology and therapeutics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Marios CharalambousUniversity of Veterinary Medicine Hannover, Hannover, Germany.ORCID https://orcid.org/0000-0002-6964-6307
Karen MuñanaNorth Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0001-9592-6276
Edward E PattersonUniversity of Minnesota, Minneapolis, Minnesota, USA.
Simon R PlattVetOracle, Diss, Norfolk, UK.ORCID https://orcid.org/0000-0002-7818-1011
Holger A VolkUniversity of Veterinary Medicine Hannover, Hannover, Germany.ORCID https://orcid.org/0000-0002-7312-638X
University of Veterinary Medicine Hannover, Foundation · DENorfolk Southern (United States) · USNorth Carolina State University · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeizure emergencies (ie, status epilepticus [SE] and cluster seizures [CS]), are common challenging disorders with complex pathophysiology, rapidly progressive drug-resistant and self-sustaining character, and high morbidity and mortality. Current treatment approaches are characterized by considerable variations, but official guidelines are lacking.

objectivesTo establish evidence-based guidelines and an agreement among board-certified specialists for the appropriate management of SE and CS in dogs and cats. ANIMALS: None. MATERIALS AND

methodsA panel of 5 specialists was formed to assess and summarize evidence in the peer-reviewed literature with the aim to establish consensus clinical recommendations. Evidence from veterinary pharmacokinetic studies, basic research, and human medicine also was used to support the panel's recommendations, especially for the interventions where veterinary clinical evidence was lacking.

resultsThe majority of the evidence was on the first-line management (ie, benzodiazepines and their various administration routes) in both species. Overall, there was less evidence available on the management of emergency seizure disorders in cats in contrast to dogs. Most recommendations made by the panel were supported by a combination of a moderate level of veterinary clinical evidence and pharmacokinetic data as well as studies in humans and basic research studies. CONCLUSIONS AND CLINICAL RELEVANCE: Successful management of seizure emergencies should include an early, rapid, and stage-based treatment approach consisting of interventions with moderate to preferably high ACVIM recommendations; management of complications and underlying causes related to seizure emergencies should accompany antiseizure medications.

Indexed as

Cat DiseasesDog DiseasesEpilepsyStatus EpilepticusAnimalsAnticonvulsantsCatsDogsEmergenciesHumansAnticonvulsantscatdogemergency seizure disorderstreatment

Identifiers

PMID37921621
PMCPMC10800221
OpenAlexW4388302415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.