Evidence map›Paper›PMID 37921561›Full record

ArticleJournal of medicinal chemistry2023

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.

Pasquale Linciano, Antonio Quotadamo, Rosaria Luciani, Matteo Santucci, Kimberley M Zorn, Daniel H Foil, Thomas R Lane, Anabela Cordeiro da Silva, Nuno Santarem, Carolina B Moraes and 12 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Multiscale-Aware Graph Embedding Approach Uncovers LC-61, a Potent Anti-Journal of chemical information and modeling · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Pasquale LincianoDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.ORCID 0000-0003-0382-7479
Antonio QuotadamoDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Rosaria LucianiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Matteo SantucciDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Kimberley M ZornCollaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Daniel H FoilCollaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Thomas R LaneCollaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.ORCID 0000-0001-9240-4763
Anabela Cordeiro da SilvaInstitute for Molecular and Cell Biology, 4150-180 Porto, Portugal.
Nuno SantaremInstitute for Molecular and Cell Biology, 4150-180 Porto, Portugal.
Carolina B MoraesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970 Campinas, São Paulo, Brazil.
Lucio Freitas-JuniorBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970 Campinas, São Paulo, Brazil.
Ulrike WittigScientific Databases and Visualization Group and Molecular and Cellular Modelling Group, Heidelberg Institute for Theoretical Studies (HITS), D-69118 Heidelberg, Germany.
Wolfgang MuellerScientific Databases and Visualization Group and Molecular and Cellular Modelling Group, Heidelberg Institute for Theoretical Studies (HITS), D-69118 Heidelberg, Germany.
Michele TonelliDepartment of Pharmacy, University of Genoa, Viale Benedetto XV n.3, 16132 Genoa, Italy.ORCID 0000-0003-1518-2890
Stefania FerrariDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.ORCID 0000-0003-1149-5953
Alberto VenturelliDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Sheraz GulFraunhofer Translational Medicine and Pharmacology, Schnackenburgallee 114, D-22525 Hamburg, Germany.ORCID 0000-0003-2543-1643
Maria KuzikovFraunhofer Translational Medicine and Pharmacology, Schnackenburgallee 114, D-22525 Hamburg, Germany.ORCID 0000-0001-8771-1865
Bernhard EllingerFraunhofer Translational Medicine and Pharmacology, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Jeanette ReinshagenFraunhofer Translational Medicine and Pharmacology, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Sean EkinsCollaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.ORCID 0000-0002-5691-5790
Maria Paola CostiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.ORCID 0000-0002-0443-5402

Funding

Centralized assay datasets for modelling support of small drug discovery organizationsR44GM122196 · NIGMS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2018 to 2022
$3.3M
MegaTox for analyzing and visualizing data across different screening systemsR43ES031038 · NIEHS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2019 to 2020
$349k
Centralized assay datasets for modelling support of small drug discovery organizationsR43GM122196 · NIGMS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2017 to 2017
$150k
NIEHS NIH HHS R43 ES031038NIGMS NIH HHS R43 GM122196NIGMS NIH HHS R44 GM122196
6 · The paper itself

Abstract

Broad-spectrum anti-infective chemotherapy agents with activity against

Indexed as

Leishmania infantumTrypanosoma brucei bruceiTrypanosoma cruziAntiparasitic AgentsHigh-Throughput Screening AssaysAntiparasitic Agents

Identifiers

PMID37921561
PMCPMC10683024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.