Evidence map›Paper›PMID 37921483›Full record

ArticleMicrobiology spectrum2023

Metabolomics insights into the polyketide-lactones produced by

Esteban Charria-Girón, Yasmina Marin-Felix, Ulrike Beutling, Raimo Franke, Mark Brönstrup, Aida M Vasco-Palacios, Nelson H Caicedo, Frank Surup

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Rapid Discovery of Antifungal α-Pyrone Analogs fromJournal of fungi (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Polyphasic characterization ofMycological progress · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Reaping the Chemical Diversity ofJournal of natural products · 2024
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Esteban Charria-GirónDepartment Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig , Braunschweig, Germany.ORCID 0000-0002-3823-1416
Yasmina Marin-FelixDepartment Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig , Braunschweig, Germany.ORCID 0000-0001-8045-4798
Ulrike BeutlingDepartment Chemical Biology, Helmholtz Centre for Infection Research GmbH (HZI) , Braunschweig, Germany.
Raimo FrankeDepartment Chemical Biology, Helmholtz Centre for Infection Research GmbH (HZI) , Braunschweig, Germany.ORCID 0000-0002-5407-5521
Mark BrönstrupDepartment Chemical Biology, Helmholtz Centre for Infection Research GmbH (HZI) , Braunschweig, Germany.ORCID 0000-0002-8971-7045
Aida M Vasco-PalaciosGrupo de Microbiología Ambiental y Grupo BioMicro, Escuela de Microbiología, Universidad de Antioquia UdeA , Medellín, Colombia.
Nelson H CaicedoDepartamento de Ciencias biológicas, Facultad de Ingeniería, Diseño y Ciencias Aplicadas, Bioprocesos y Biotecnología, Universidad Icesi , Cali, Colombia.ORCID 0000-0002-2133-7994
Frank SurupDepartment Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig , Braunschweig, Germany.ORCID 0000-0001-5234-8525
Helmholtz Centre for Infection Research · DEIcesi University · COUniversidad de Antioquia · CO

Funding

Deutsche Forschungsgemeinschaft (DFG) 490821847Helmholtz-Fonds (Helmholtz-Fonds e.V.) CCC grantMinisterio de Ciencia, Tecnología, Conocimiento e Innovación (CTCI) 22028Primer Proyecto, project 2020 33675
6 · The paper itself

Abstract

importanceThe integration of metabolomics-based approaches into the discovery pipeline has enabled improved mining and prioritization of prolific secondary metabolite producers such as endophytic fungi. However, relying on automated untargeted analysis tools might lead to misestimation of the chemical complexity harbored in these organisms. Our study emphasizes the importance of isolation and structure elucidation of the respective metabolites in addition to deep metabolome analysis for the correct interpretation of untargeted metabolomics approaches such as molecular networking. Additionally, it encourages the further exploration of endophytic fungi from traditional medicinal plants for the discovery of natural products.

Indexed as

Plants, MedicinalPolyketidesEndophytesFungiLactonesMetabolomicsLactonesPolyketidesantibioticsdereplicationmetabolomicsnatural productsNMRsecondary metabolitesstructure elucidation

Identifiers

PMID37921483
PMCPMC10715209
OpenAlexW4388290717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.