Evidence map›Paper›PMID 37921438›Full record

ArticleAnaesthesia2024

A quantitative evaluation of aerosol generation during cardiopulmonary resuscitation.

A J Shrimpton, V Brown, J Vassallo, J P Nolan, J Soar, F Hamilton, T M Cook, B R Bzdek, J P Reid, C H Makepeace and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

A J ShrimptonAnaesthesia, Pain and Critical Care Sciences, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.ORCID 0000-0001-6790-909X
V BrownCritical Care, South Western Ambulance Service NHS Foundation Trust, UK.
J VassalloInstitute of Naval Medicine, Gosport, UK.
J P NolanUniversity of Warwick, Warwick Medical School, Coventry, UK.ORCID 0000-0003-3141-3812
J SoarDepartment of Anaesthesia and Intensive Care Medicine, North Bristol NHS Trust, Bristol, UK.ORCID 0000-0001-5970-6073
F HamiltonMRC Integrative Epidemiology Unit, University of Bristol, UK.ORCID 0000-0002-9760-4059
T M CookDepartment of Anaesthesia and Intensive Care Medicine, Royal United Hospital, Bath, UK.ORCID 0000-0002-3654-497X
B R BzdekSchool of Chemistry, University of Bristol, Bristol, UK.ORCID 0000-0003-2234-1079
J P ReidSchool of Chemistry, University of Bristol, Bristol, UK.ORCID 0000-0001-6022-1778
C H MakepeaceLangford Vets and Translational Biomedical Research Centre, University of Bristol, UK.
J DeutschLangford Vets and Translational Biomedical Research Centre, University of Bristol, UK.
R AscioneTranslational Biomedical Research Centre, University of Bristol, Bristol, UK.ORCID 0000-0001-8045-5619
J M BrownDepartment of Anaesthesia and Intensive Care Medicine, North Bristol NHS Trust, Bristol, UK.
J R BengerFaculty of Health and Applied Sciences, University of the West of England, Bristol, UK.ORCID 0000-0001-6131-0916
A E PickeringDepartment of Anaesthesia, University Hospitals Bristol and Weston, Bristol, UK.ORCID 0000-0003-0345-0456
University of Bristol · GBNorth Bristol NHS Trust · GBRoyal United Hospital · GBRoyal Hospital Haslar · GBSouth Western Ambulance Service NHS Foundation Trust · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity of the West of England · GB

Funding

British Heart Foundation RM/21/290001Medical Research Council MR/L012723/1Wellcome TrustWellcome Trust 222894/Z/21/Z
6 · The paper itself

Abstract

It is unclear if cardiopulmonary resuscitation is an aerosol-generating procedure and whether this poses a risk of airborne disease transmission to healthcare workers and bystanders. Use of airborne transmission precautions during cardiopulmonary resuscitation may confer rescuer protection but risks patient harm due to delays in commencing treatment. To quantify the risk of respiratory aerosol generation during cardiopulmonary resuscitation in humans, we conducted an aerosol monitoring study during out-of-hospital cardiac arrests. Exhaled aerosol was recorded using an optical particle sizer spectrometer connected to the breathing system. Aerosol produced during resuscitation was compared with that produced by control participants under general anaesthesia ventilated with an equivalent respiratory pattern to cardiopulmonary resuscitation. A porcine cardiac arrest model was used to determine the independent contributions of ventilatory breaths, chest compressions and external cardiac defibrillation to aerosol generation. Time-series analysis of participants with cardiac arrest (n = 18) demonstrated a repeating waveform of respiratory aerosol that mapped to specific components of resuscitation. Very high peak aerosol concentrations were generated during ventilation of participants with cardiac arrest with median (IQR [range]) 17,926 (5546-59,209 [1523-242,648]) particles.l

Indexed as

Cardiopulmonary ResuscitationOut-of-Hospital Cardiac ArrestAnimalsExhalationHeartHumansRespirationSwineaerosol-generating procedurecardiopulmonary resuscitationCPRout-of-hospital cardiac arrest

Identifiers

PMID37921438
PMCPMC10952244
OpenAlexW4388291023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.