Evidence map›Paper›PMID 37921408›Full record

ArticleCancer biology & medicine2023

TNFSF15 facilitates the differentiation of CD11b

Xiangxiang Gu, Yipan Zhu, Cancan Zhao, Yixin Cao, Jingying Wang, Qiangzhe Zhang, Luyuan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiangxiang GuState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.
Yipan ZhuState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.
Cancan ZhaoState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.
Yixin CaoState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.
Jingying WangState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.ORCID 0009-0002-1926-1596
Qiangzhe ZhangState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.ORCID 0000-0003-0874-1818
Luyuan LiState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, and Haihe Laboratory of Cell Ecosystem, Tianjin 300350, China.ORCID 0000-0003-1912-3556
Nankai University · CN

Funding

Haihe Laboratory of Cell Ecosystem Innovation Fund 22HHXBSS00020 to LYLMinistry of Education 111 Project B20016 to LYLNational Natural Science Foundation of China 81874167 to LYLNational Natural Science Foundation of China 82073064National Natural Science Foundation of China 82073233 to ZQZ
6 · The paper itself

Abstract

objectiveImmature vasculature lacking pericyte coverage substantially contributes to tumor growth, drug resistance, and cancer cell dissemination. We previously demonstrated that tumor necrosis factor superfamily 15 (TNFSF15) is a cytokine with important roles in modulating hematopoiesis and vascular homeostasis. The main purpose of this study was to explore whether TNFSF15 might promote freshly isolated myeloid cells to differentiate into CD11b

methodsA model of Lewis lung cancer was established in mice with red fluorescent bone marrow. After TNFSF15 treatment, CD11b

resultsWe observed elevated percentages of bone marrow-derived CD11b

conclusionsTNFSF15 facilitates the production of CD11b

Indexed as

NeoplasmsPericytesAnimalsCell DifferentiationEndothelial CellsHumansMiceMice, Inbred C57BLMyeloid CellsTumor Necrosis Factor Ligand Superfamily Member 15Tumor Necrosis FactorsTNFSF15 protein, humanTnfsf15 protein, mouseTumor Necrosis Factor Ligand Superfamily Member 15Tumor Necrosis FactorsCD11bmyeloid cellneovascularizationpericyteTNFSF15

Identifiers

PMID37921408
PMCPMC10690882
OpenAlexW4388293426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.