Evidence map›Paper›PMID 37921179›Full record

ReviewCurrent medicinal chemistry2024

From Plants to Therapies: Exploring the Pharmacology of Coumestrol for Neurological Conditions.

Madhav Singla, Smriti Verma, Kiran Thakur, Ahsas Goyal, Vishal Sharma, Diksha Sharma, Omji Porwal, Vetriselvan Subramaniyan, Tapan Behl, Sachin Kumar Singh and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 4 countries.

Madhav SinglaChitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Smriti VermaChitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Kiran ThakurChitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Ahsas GoyalDepartment of Pharmacy, Institute of Pharmaceutical Research, GLA University, U.P., India.
Vishal SharmaM.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, India.
Diksha SharmaDepartment of Pharmacy, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, 136119, India.
Omji PorwalDepartment of Pharmacognosy, Faculty of Pharmacy, Ishik University, Erbil, Kurdistan, Iraq.
Vetriselvan SubramaniyanPharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.
Tapan BehlDepartment of Pharmacy, School of Health Science and Technology, University of Petroleum Science and Energy Studies, Dehradun, Uttarakhand, India.
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
Kamal DuaFaculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, 2007, Australia.
Gaurav GuptaSchool of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India.
Saurabh GuptaChitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Chitkara University · INGLA University · INKurukshetra University · INLovely Professional University · INMaharishi Markandeshwar University, Mullana · INMonash University Malaysia · MYTishk International University · IQUniversity of Petroleum and Energy Studies · INUniversity of Technology Sydney · AUUttaranchal University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological disorders are possibly the most prevalent and have been identified to occur among individuals with autism beyond chance. These disorders encompass a diverse range of consequences with neurological causes and have been regarded as a major threat to public mental health. There is no tried-and-true approach for completely protecting the nervous system. Therefore, plant-derived compounds have developed significantly nowadays. Coumestrol (CML) is a potent isoflavone phytoestrogen with a protective effect against neurological dysfunction and has been discovered to be structurally and functionally similar to estrogen. In recent years, more research has been undertaken on phytoestrogens. This research demonstrates the biological complexity of phytoestrogens, which consist of multiple chemical families and function in various ways. This review aimed to explore recent findings on the most significant pharmacological advantages of CML by emphasising neurological benefits. Numerous CML extraction strategies and their pharmacological effects on various neurological disorders, including PD, AD, HD, anxiety, and cognitive impairments, were also documented.

Indexed as

CoumestrolNervous System DiseasesAnimalsHumansNeuroprotective AgentsPhytoestrogensCoumestrolNeuroprotective AgentsPhytoestrogensAD.Coumestrolneurological diseasesPDpharmacological aspectsphytoestrogen

Identifiers

PMID37921179
OpenAlexW4388302600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.