Evidence map›Paper›PMID 37921058›Full record

ArticleMolecular medicine reports2023

A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats.

Aristidis Tsatsakis, Elisavet Renieri, Dimitris Tsoukalas, Ana Maria Buga, Evangelia Sarandi, Elena Vakonaki, Persefoni Fragkiadaki, Athanasios Alegakis, Dragana Nikitovic, Daniela Calina and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Zinc in psychosis (Review).Molecular medicine reports · 2025
    Review
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Aristidis TsatsakisLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 10674 Athens, Greece.
Elisavet RenieriLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 10674 Athens, Greece.
Dimitris TsoukalasMetabolomic Medicine, Health Clinic for Autoimmune and Chronic Diseases, 10674 Athens, Greece.
Ana Maria BugaDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Evangelia SarandiLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 10674 Athens, Greece.
Elena VakonakiLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 10674 Athens, Greece.
Persefoni FragkiadakiLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 10674 Athens, Greece.
Athanasios AlegakisLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 10674 Athens, Greece.
Dragana NikitovicLaboratory of Histology‑Embryology, Medical School, University of Crete, 71003 Heraklion, Greece.
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Demetrios A SpandidosLaboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece.
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
University of Crete · GRUniversity of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomeres are major contributors to cell fate and aging through their involvement in cell cycle arrest and senescence. The accelerated attrition of telomeres is associated with aging‑related diseases, and agents able to maintain telomere length (TL) through telomerase activation may serve as potential treatment strategies. The aim of the present study was to assess the potency of a novel telomerase activator on TL and telomerase activity

Indexed as

TelomeraseAnimalsDietary SupplementsLeukocytes, MononuclearRatsTelomereTelomere ShorteningTelomeraseCentella asiaticadietary supplementsin vivotelomerase activitytelomere length

Identifiers

PMID37921058
PMCPMC10668076
OpenAlexW4388185503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.