Evidence map›Paper›PMID 37920668›Full record

ArticleiScience2023

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons.

Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J Rodriguez, Durgadevi Alagappan, Su Min Lim and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Exploring dysregulated miRNAs in ALS: implications for disease pathogenesis and early diagnosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. The role of tribbles homolog 2 in cell proliferation.Cell communication and signaling : CCS · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 4 countries.

Wan Yun HoDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Li-Ling ChakDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Jin-Hui HorInstitute of Molecular and Cellular Biology, A∗STAR Research Entities, 61 Biopolis Drive, Singapore 138673, Singapore.
Fujia LiuDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Sandra Diaz-GarciaDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Jer-Cherng ChangDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Emma SanfordDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Maria J RodriguezDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Durgadevi AlagappanDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Su Min LimDepartment of Neurology, Biomedical Research Institute, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
Yik-Lam ChoDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Yuji ShimizuNara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Alfred Xuyang SunPrograms in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.
Sheue-Houy TyanDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Edward KooDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Seung Hyun KimDepartment of Neurology, Biomedical Research Institute, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
John RavitsDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Shi-Yan NgInstitute of Molecular and Cellular Biology, A∗STAR Research Entities, 61 Biopolis Drive, Singapore 138673, Singapore.
Katsutomo OkamuraTemasek Lifesciences Laboratory, Singapore 117604, Singapore.
Shuo-Chien LingDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
National University of Singapore · SGUniversity of California San Diego · USAgency for Science, Technology and Research · SGHanyang University · KRTemasek Life Sciences Laboratory · SGDuke-NUS Medical School · SGNara Institute of Science and Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS). As fused in sarcoma (FUS) is a causal gene for ALS and regulates biogenesis of miRNAs, we systematically analyzed the miRNA repertoires in spinal cords and hippocampi from ALS-FUS mice to understand how FUS-dependent miRNA deregulation contributes to ALS. miRNA profiling identified differentially expressed miRNAs between different central nervous system (CNS) regions as well as disease states. Among the up-regulated miRNAs, miR-1197 targets the pro-survival pseudokinase

Indexed as

Cellular neuroscienceNatural sciencesNeurosciencePhysiologySystems neuroscience

Identifiers

PMID37920668
PMCPMC10618709
OpenAlexW4387409153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.