ArticleFrontiers in psychiatry2023
Depression and risk of sarcopenia: a national cohort and Mendelian randomization study.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Climate Change and Sarcopenia: Mechanisms, Vulnerabilities, and Public Health Implications.Calcified tissue international · 2026Review
- Association of depression with sarcopenia and the impact of sleep: the first longitudinal evidence from the CHARLS.BMC public health · 2026Article
- A body shape index and sarcopenia risk in middle-aged and older adults: evidence from the China Health and Retirement Longitudinal Study.European journal of medical research · 2025Article
- The association of loneliness with bone mineral density, osteoporosis, osteopenia, fall, and sarcopenia among older adults: results from Mr. and Ms. Os (Hong Kong) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Can malnutrition, dietary habits, and diet quality be determinant factors in frailty, sarcopenia, low physical function, and depression in older adults?BMC geriatrics · 2025Article
- Possible sarcopenia and associated factors in community-dwelling older adults with a history of falls in the Republic of Korea: a cross-sectional study.BMC geriatrics · 2025Article
- The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross-Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS).Brain and behavior · 2025Article
- The impact of chronic diseases and lifestyle on sarcopenia risk in older adults: a population-based longitudinal study.Frontiers in medicine · 2025Article
- Possible sarcopenia and depression among middle-aged and older adults in China: A 9-year longitudinal survey.PloS one · 2025Article
- The association between circadian syndrome and possible sarcopenia in an aging population: A 4-year follow-up study.PloS one · 2025Article
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis.Open medicine (Warsaw, Poland) · 2025Review
- Effect of subanesthetic dose of esketamine on early postoperative depression in elderly patients with Sarcopenia.Journal of orthopaedic surgery and research · 2024Article
- Association between sleep duration and sleep quality with pre-sarcopenia in the 20-59-year-old population: evidence from the National Health and Nutrition Examination Surveys 2005-2014.Archives of public health = Archives belges de sante publique · 2024Article
- Construction and evaluation of sarcopenia risk prediction model for patients with diabetes: a study based on the China health and retirement longitudinal study (CHARLS).Diabetology & metabolic syndrome · 2024Article
- Relationships between sarcopenia, depressive symptoms, and the risk of cardiovascular disease in Chinese population.The journal of nutrition, health & aging · 2024Article
- Bidirectional Association between Sarcopenia and Depressive Symptoms among Chinese Middle- and Older-Aged Adults: Longitudinal Observational Study.Brain sciences · 2024Article
- Association between persistent musculoskeletal pain and incident sarcopenia in China: the mediating effect of depressive symptoms.Frontiers in public health · 2024Article
- Prevalence of Sarcopenia and Its Association with Mental Health Status in Elderly Patients: A Comparative Cross-sectional Study.Journal of mid-life healthArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression and the increased risk of sarcopenia are prevalent among the elderly population. However, the causal associations between these factors remain unclear. To investigate the potential association between depression and the risk of sarcopenia in older adults, this study was performed. Methods: In the baseline survey, a total of 14,258 individuals aged 40 and above from the China Health and Retirement Longitudinal Study (2015) participated. We initially described the baseline prevalence of the disease. Then, logistic regression and restricted cubic spline (RCS) regression were conducted to assess the relationship between depression and sarcopenia. Subgroup analysis was performed to validate the robustness of the findings. Additionally, we conducted Mendelian randomization analysis using the inverse variance weighting estimator to assess the causal relationship between depression and sarcopenia. Furthermore, we adopted six methods, including MR-Egger, simple median, weighted median, maximum likelihood, robust adjusted profile score (RAPS), and MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), for sensitivity analyses. Results: Depression patients exhibited higher risks of sarcopenia in all five models adjusting for different covariates ( Conclusion: Our study provides observational and causal evidences that depression can lead to sarcopenia. This finding emphasizes the importance of timely identification and management of depression, as well as implementing targeted educational programs as part of comprehensive strategies to prevent sarcopenia.
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