Precise Construction of Dual-Promising Anticancer Drugs Associated with Gold Nanomaterials on Glioma Cancer Cells.

P Baby Shakila, Abdurahman Hajinur Hirad, Abdullah A Alarfaj, Samer Hasan Hussein-Al-Ali, Beza Mulugeta

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Article in Bioinorganic chemistry and applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

P Baby ShakilaDepartment of Biochemistry, Vivekananda College of Arts and Sciences for Women, Tiruchengode 637205, Tamil Nadu, India.

Abdurahman Hajinur HiradDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

Abdullah A AlarfajDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

Samer Hasan Hussein-Al-AliDepartment of Chemistry, Faculty of Science, Isra University, Amman 11622, Jordan.

Beza MulugetaDepartment of Food Science and Postharvest Technology, Haramaya Institute of Technology, Haramaya University, Dire Dawa, P.O. Box 128, Ethiopia.ORCID https://orcid.org/0009-0006-8917-0250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple chemodrugs with nanotechnology have proven to be an effective cancer treatment technique. When taken combined, cabazitaxel (CTX) and cisplatin (PT) have more excellent cytotoxic effects than drugs used alone in the chemotherapy of several different cancers. However, several severe side effects are associated with using these chemotherapy drugs in cancer patients. Gold nanomaterials (AuNMs) are promising as drug carriers because of their small diameter, easy surface modifications, good biocompatibility, and strong cell penetration. This work aimed to determine the CTX and PT encapsulated with AuNMs against human glioma U87 cancer cells. The fabrication of the AuNMs achieved a negative surface charge, polydispersity index, and the mean sizes. The combined cytotoxic effect of CTX and PT bound to AuNMs was greater than that of either drug alone when tested on U87 cells. The half inhibitory concentration (IC

Identifiers

PMID37920234

DOI10.1155/2023/8892099

PMCPMC10620031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.