Evidence map›Paper›PMID 37919918›Full record

ReviewAnesthesia and pain medicine2023

Does adding muscle relaxant make post-operative pain better? a narrative review of the literature from US and European studies.

Ricardo Verdiner, Narjeet Khurmi, Christopher Choukalas, Colby Erickson, Karl Poterack

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesia and pain medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664956 (Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07664956 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy: A Randomized Controlled Trial

TypeinterventionalSponsorChristiana Care Health ServicesRan2026 to 2026Enrolled36ConditionsMinimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified, Adenomyosis of Uterus, Fibroid UterusArmsCyclobenzaprine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ricardo VerdinerDepartment of Anesthesiology, Mayo Clinic, Phoenix, AZ, USA.
Narjeet KhurmiDepartment of Anesthesiology, Mayo Clinic, Phoenix, AZ, USA.
Christopher ChoukalasDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, USA.
Colby EricksonDepartment of Anesthesia and Perioperative Care, Midwestern Osteopathic Medical School, Glendale, CA, USA.
Karl PoterackDepartment of Anesthesiology, Mayo Clinic, Phoenix, AZ, USA.
Mayo Clinic Hospital · USMidwestern University · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Centrally acting skeletal muscle relaxants (CASMR) are widely prescribed as adjuncts for acute and chronic pain. Given the recent interest in multimodal analgesia and reducing opioid consumption, there has been an increase in its use for perioperative/postoperative pain control. The mechanism of action, pharmacodynamics, and pharmacokinetics of these drugs vary. Their use has been studied in a wide range of operative and non-operative settings. The best evidence for the efficacy of CASMRs is in acute, nonoperative musculoskeletal pain and, in the operative setting, in patients undergoing total knee arthroplasty and abdominal surgery, including inguinal herniorrhaphy and hemorrhoidectomy. The risk of complications and side effects, coupled with the limited evidence of efficacy, should prompt careful consideration of individual patient circumstances when prescribing CASMRs as part of perioperative pain management strategies.

Indexed as

AnalgesicsMuscleMuscle relaxantPainPain managementSubstance-related disorders.

Identifiers

PMID37919918
PMCPMC10635846
OpenAlexW4388076804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.