Evidence map›Paper›PMID 37919818›Full record

ArticleMaternal health, neonatology and perinatology2023

Sub-optimal maternal gestational gain is associated with shorter leukocyte telomere length at birth in a predominantly Latinx cohort of newborns.

Apurva Prasad, Jue Lin, Laura Jelliffe-Pawlowski, Kimberley Coleman-Phox, Larry Rand, Janet M Wojcicki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal health, neonatology and perinatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Apurva PrasadDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, USA.
Laura Jelliffe-PawlowskiPreterm Birth Initiative, University of California, San Francisco, USA.
Kimberley Coleman-PhoxDepartment of Obstetrics, Gynecology and Reproductive Health Sciences, University of California, San Francisco, USA.
Larry RandDepartment of Obstetrics, Gynecology and Reproductive Health Sciences, University of California, San Francisco, USA.
Janet M WojcickiDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, USA. Janet.wojcicki@ucsf.edu.ORCID http://orcid.org/0000-0002-3393-1368
University of California, San Francisco · US

Funding

Little Giraffe Foundation WojcickiUCSF Preterm Birth Initiative Wojcicki
6 · The paper itself

Abstract

objectiveTo assess in utero exposures associated with leukocyte telomere length (LTL) at birth and maternal LTL in a primarily Latinx birth cohort. STUDY

designMothers and newborns were recruited postnatally before 24 h of life. Newborn LTL was collected via heelstick at birth and maternal LTL was collected postnatally. LTL was determined by quantitative PCR. Using a longitudinal design, we evaluated associations between neonatal and maternal LTL and appropriate maternal gestational gain as indicated by the American College of Obstetrics and Gynecology (ACOG).

resultMean infant LTL was 2.02 ± 0.30 T/S (n = 386) and maternal LTL was 1.54 ± 0.26 T/S (n = 58). Independent risk factors for shorter LTL at birth included longer gestational duration (Coeff:-0.03, 95%CI: -0.05-0.01;p < 0.01) and maternal gestational weight gain below ACOG recommendations (Coeff:-0.10, 95%CI: -0.18 - -0.02; p = 0.01).

conclusionGestational weight gain below ACOG recommendations may adversely impact neonatal health in Latinx infants as indicated by shorter LTL at birth.

Identifiers

PMID37919818
PMCPMC10623801
OpenAlexW4388248625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.