ArticleBMC geriatrics2023
Sex-modified association between grip strength and mild cognitive impairment: a cross-sectional and follow-up study in rural China.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.British journal of sports medicine · 2026Pooled it
- Differential Improvement in Memory and Executive Functions: Personalized Exercise versus Acupuncture for Mild Cognitive Impairment in Stroke-prone Individuals.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Diagnostic value of Montreal cognitive assessment combined with olfactory tests for mild cognitive impairment in older adult patients with type 2 diabetes.European geriatric medicine · 2025Article
- The relationship between hearing loss and cognitive function in the elderly: the mediating effect of social isolation.BMC geriatrics · 2025Article
- Physical fitness and incident mild cognitive impairment: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- Cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning among people aged 50 years and older: evidence from two longitudinal cohort studies.Archives of public health = Archives belges de sante publique · 2025Article
- The Longitudinal Relationship Between Physical Functions and Cognitive Functions Among Middle-Aged and Older Adults in Primary Care.International journal of environmental research and public health · 2025Article
- Impact of scheduled water intake on mild cognitive impairment in patients with orthostatic hypotension.Scientific reports · 2025Article
- Association between physical activity levels and mild cognitive impairment in Chinese older adults: a cross-sectional study from the China health and retirement longitudinal study.Frontiers in public health · 2025Article
- Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.American journal of translational research · 2025Article
- Exploring the Connections Between Grip Strength, Nutritional Status, Frailty, Depression, and Cognition as Initial Assessment Tools in Geriatric Rehabilitation-A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Article
- Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.Neuro-degenerative diseases · 2024Article
- Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status.Frontiers in nutrition · 2024Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sex difference in the association between grip strength and mild cognitive impairment (MCI) remains controversial and unclear.
methodsThis is a part of a chronic disease cohort study conducted in rural areas, Fuxin, Liaoning Province, China. At the baseline survey, a total of 2633 participants aged 35- 85 were included in the cross-sectional study. Handgrip strength (HGS, kg) was measured by a dynamometer (Jamar +). MCI were assessed using the Chinese version of the Montreal Cognitive Assessment-Basic (MOCA-BC). Then, a total of 1667 cognitively normal individuals (NCs) were planed to follow up and to assess the incident MCI after two years. We used logistic regression to examine the association between HGS (as a continuous variable and quintiles) and MCI and analyzed the interaction between sex and HGS on MCI. Models stratified by sex were adjusted for demographic information (age, ethnicity, education, marital status, income, physical labor level), modifiable risk factors (body mass index, smoking, drinking) and disease history (hypertension, diabetes, dyslipidemia and coronary heart disease). Baseline MOCA-BC scores were additionally adjusted in the longitudinal study.
resultsIn the cross-sectional study, participants were on average 56.6 ± 9.8 years, and 1713 (65.1%) were females. In the cohort study, 743 individuals were followed up with an average age of 55.9 ± 9.6 years, which included 530 (71.3%) females. The cumulative incidence of MCI over a two-year period was 17.1%. In the cross-sectional study, compared to the highest quintile of HGS, the lowest HGS was associated with higher risk of MCI in males (odds ratio [OR]: 2.66; 95% confidence interval [CI]: 1.54, 4.64) and females (OR: 1.70; 95% CI: 1.17, 2.49) with adjustment of potential confounding factors. In the cohort study, compared to the highest quintile of HGS, the lowest HGS was associated with an increased risk of incident MCI in females (OR: 3.93; 95% CI: 1.39, 13.01) but not in males (OR: 0.56; 95% CI: 0.11, 2.94, P
conclusionsLower grip strength is a risk factor for mild cognitive impairment and predicts a higher risk of MCI in females.
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