Evidence map›Paper›PMID 37919644›Full record

ArticleBMC cancer2023

Sex-specific aspects in patients with oropharyngeal squamous cell carcinoma: a bicentric cohort study.

Charlotte Klasen, Nora Wuerdemann, Pauline Rothbart, Johanna Prinz, Hans Nicholaus Casper Eckel, Malte Suchan, Christopher Kopp, Jannik Johannsen, Maria Ziogas, Arthur Charpentier and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Sex and gender differences in cancer pathogenesis and pharmacology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Charlotte Klasen *Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany. charlotte.klasen1@uk-koeln.de.
Nora Wuerdemann *Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Pauline RothbartDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Johanna PrinzCenter for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.
Hans Nicholaus Casper EckelDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Malte SuchanDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Christopher KoppDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Jannik JohannsenDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Maria ZiogasDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Arthur CharpentierDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Christian Ulrich HuebbersDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Shachi Jenny SharmaDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Christine LangerDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Giessen, Klinikstrasse 33, Giessen, Germany.
Christoph ArensDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Giessen, Klinikstrasse 33, Giessen, Germany.
Steffen Wagner *Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Giessen, Klinikstrasse 33, Giessen, Germany.
Alexander Quaas *Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.
Jens Peter Klußmann *Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.

Funding

German Research Council (FI 773/15-1)
6 · The paper itself

Abstract

backgroundOropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other cancer entities have revealed differences in treatment response and prognosis. However, only limited data in OPSCC according to gender and human papillomavirus (HPV) status exist. Therefore, we aimed to investigate sex-specific differences in OPSCC and how these may be distributed in relation to HPV and other risk factors.

methodsThis retrospective, bicentric study included 1629 patients with OPSCC diagnosed between 1992 and 2020. We formed subgroups based on TNM status, American Joint Cancer Committee 8

resultsWith the exception of alcohol abuse, no significant differences were found in risk factors between men and women. Females presented with better OS than males in the subgroup T1-2, N + , independent of risk factors (p = 0.008). Males demonstrated significant stratification through all AJCC8 stages (all p < 0.050). In contrast, women were lacking significance between stage II and III (p = 0.992). With regard to therapy (surgery (± R(C)T) - vs. definitive RCT) women treated with surgery had better OS than men in the whole cohort (p = 0.008). Similar results were detected in the HPV-negative OPSCC sub-cohort (p = 0.042) and in high-risk groups (AJCC8 stage III and IV with M0, p = 0.003).

conclusionSex-specific differences in OPSCC represent a health disparity, particularly according to staging and treatment, which need to be addressed in future studies.

Indexed as

Head and Neck NeoplasmsOropharyngeal NeoplasmsPapillomavirus InfectionsCohort StudiesFemaleHuman Papillomavirus VirusesHumansMaleNeoplasm StagingPapillomaviridaePrognosisRetrospective StudiesSquamous Cell Carcinoma of Head and NeckEpidemiologyGenderHuman papillomavirus (HPV)Oropharyngeal squamous cell carcinoma (OPSCC)PrognosisSurvival

Identifiers

PMID37919644
PMCPMC10621233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.