ArticleNature genetics2023
An atlas of genetic determinants of forearm fracture.
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Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16citing papers in PubMed, 1 pooled it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Body mass index and subsequent fracture risk: a meta-analysis to update FRAX.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Pooled it
- Protective role of hemokinin-1 against age-dependent spatial memory and attention decline in mice.GeroScience · 2026Article
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- Widespread neuronal hemokinin-1 expression in motor regions and its protective role in age-related impairment.GeroScience · 2026Article
- Validation of fracture-derived polygenic scores with FRAX for fracture risk prediction in postmenopausal women.Archives of osteoporosis · 2026Article
- Muscle Function and Bone Strength in Children and Adolescents with Tall Stature.Hormone research in paediatrics · 2026Article
- Role of Complement Component 9 in Bone Health: Causal Evidence in Humans and Mechanistic Studies in Mice.Calcified tissue international · 2026Article
- Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Identification of ephrin-A1-EphA2 signalling as a potential target for fracture prevention.Nature communications · 2026Article
- Can AI reveal the next generation of high-impact bone genomics targets?Bone reports · 2025Review
- Wnt family members regulating osteogenesis and their origins.Journal of bone and mineral metabolism · 2025Review
- High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific Data.Calcified tissue international · 2024Article
- Valid inference for machine learning-assisted genome-wide association studies.Nature genetics · 2024Article
- Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- GREM2 inactivation increases trabecular bone mass in mice.Scientific reports · 2024Article
- Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
37 authors at 16 institutions in 10 countries.
Maria Nethander *Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-3688-906X
Sofia Movérare-Skrtic *Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-7982-7438
Anders KämpeDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1829-3855
Eivind CowardK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Ene ReimannEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5410-4433
Louise GrahnemoDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-5276-6612
Éva BorbélyDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Zsuzsanna HelyesDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Thomas Funck-BrentanoBIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France.
Martine Cohen-SolalBIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France.ORCID 0000-0002-8582-8258
Juha TuukkanenDepartment of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-1723-6461
Antti KoskelaDepartment of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland.
Jianyao WuDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lei LiDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tianyuan LuLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.ORCID 0000-0002-5664-5698
Maiken E GabrielsenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Estonian Biobank Research Team
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-2964-6011
Mari HoffDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Ulf H LernerDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Petra HenningDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Henrik UllumStatens Serum Institut, Copenhagen, Denmark.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6551-6647
Søren BrunakNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0316-5866
DBDS Genomic Consortium
Arnulf LanghammerFaculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID 0000-0001-5296-6673
Tiinamaija TuomiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-8306-6202
Asmundur OddssondeCODE genetics, Reykjavik, Iceland.ORCID 0000-0002-4606-5163
Kari StefanssondeCODE genetics, Reykjavik, Iceland.
Ulrika Pettersson-KymmerDepartment of Integrative Medical Biology, Clinical Pharmacology, Umea University, Umea, Sweden.
Sisse Rye OstrowskiDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5288-3851
Ole Birger Vesterager PedersenDepartment of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2312-5976
Unnur StyrkarsdottirdeCODE genetics, Reykjavik, Iceland.
Outi MäkitieDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4547-001X
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
J Brent RichardsLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.ORCID 0000-0002-3746-9086
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. claes.ohlsson@medic.gu.se.ORCID 0000-0002-9633-2805
University of Gothenburg · SENorwegian University of Science and Technology · NOdeCODE Genetics (Iceland) · ISUniversity of Copenhagen · DKUniversity of Helsinki · FIInserm · FRUniversity of Oulu · FIUniversity of Pecs · HUUniversity of Tartu · EEAarhus University · DKJewish General Hospital · CAKing's College London · GBSahlgrenska University Hospital · SEStatens Serum Institut · DKUmeå University · SEUniversity of Iceland · IS
Funding
Wellcome Trust
Abstract
Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci. Although most fracture loci associated with bone mineral density, we also identified loci that primarily regulate bone quality parameters. Functional studies of one such locus, at TAC4, revealed that Tac4
Indexed as
ForearmFractures, BoneAnimalsBone DensityGenome-Wide Association StudyMiceRisk Factors
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