ArticleNature genetics2023
Single-haplotype comparative genomics provides insights into lineage-specific structural variation during cat evolution.
Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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22 citing papers in PubMed, 32 citations in OpenAlex.
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- First Genome Assembly of the Critically Endangered Arabian Leopard (International journal of molecular sciences · 2026Article
- Conserved host genes act as anchors for fast-evolving piRNA clusters via promoter hijacking.Research square · 2026Article
- Mutation rate estimate and population genomic analysis reveals decline of koalas prior to human arrival.Molecular biology and evolution · 2026Article
- Genome Scans Reveal Species-Specific Selection in the Genus Lynx.Genome biology and evolution · 2026Article
- The tiger who came to T2T: Telomere-to-Telomere genome assembly of the Sumatran tiger (Panthera tigris sumatrae) using nanopore simplex reads.BMC genomics · 2026Article
- Pangenome analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility.Genome research · 2026Article
- A hypomorphic SRD5A2 haplotype with a potential founder effect: composed of common variants in individuals with 5α-reductase type 2 deficiency from South China.Biology of sex differences · 2026Article
- From individuals to communities: How genomics is transforming biodiversity conservation.Genetics and molecular biology · 2026Article
- Haplotype-resolved T2T genome assembly of the Populus nigra NL-1976.Scientific data · 2025Article
- The haplotype-resolved and near telomere-to-telomere genome assembly for Hypsebarbus vernayi.Scientific data · 2025Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Comparative Genomics of Sex-Determination-Related Genes Reveals Shared Evolutionary Patterns Between Bivalves and Mammals, but Not Fruit Flies.Molecular ecology · 2025Article
- A chromosome-level genome assembly of the mountain lion, Puma concolor.The Journal of heredity · 2025Article
- Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae).BMC genomics · 2025Article
- The value of hybrid genomes: Building two highly contiguous reference genome assemblies to advance Canis genomic studies.The Journal of heredity · 2024Article
- Toward telomere-to-telomere cat genomes for precision medicine and conservation biology.Genome research · 2024Review
- Ancestry dynamics and trait selection in a designer cat breed.Current biology : CB · 2024Article
- A chromosome-scale fishing cat reference genome for the evaluation of potential germline risk variants.Scientific reports · 2024Article
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
The role of structurally dynamic genomic regions in speciation is poorly understood due to challenges inherent in diploid genome assembly. Here we reconstructed the evolutionary dynamics of structural variation in five cat species by phasing the genomes of three interspecies F1 hybrids to generate near-gapless single-haplotype assemblies. We discerned that cat genomes have a paucity of segmental duplications relative to great apes, explaining their remarkable karyotypic stability. X chromosomes were hotspots of structural variation, including enrichment with inversions in a large recombination desert with characteristics of a supergene. The X-linked macrosatellite DXZ4 evolves more rapidly than 99.5% of the genome clarifying its role in felid hybrid incompatibility. Resolved sensory gene repertoires revealed functional copy number changes associated with ecomorphological adaptations, sociality and domestication. This study highlights the value of gapless genomes to reveal structural mechanisms underpinning karyotypic evolution, reproductive isolation and ecological niche adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.