Evidence map›Paper›PMID 37919449›Full record

ArticleAnnals of surgical oncology2024

Prognostic Impact of Stromal Profiles Educated by Gastric Cancer.

Kazunori Takahashi, Katsutoshi Shoda, Koichi Takiguchi, Yudai Higuchi, Koichi Matsuoka, Takashi Nakayama, Ryo Saito, Suguru Maruyama, Yuki Nakata, Shinji Furuya and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Kazunori Takahashi *First Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Katsutoshi ShodaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. kshoda@yamanashi.ac.jp.
Koichi Takiguchi *First Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Yudai HiguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Koichi MatsuokaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Takashi NakayamaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Ryo SaitoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Suguru MaruyamaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Yuki NakataFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Shinji FuruyaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Kensuke ShiraishiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Hidenori AkaikeFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Yoshihiko KawaguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Hidetake AmemiyaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Hiromichi KawaidaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Daisuke IchikawaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
University of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer-associated fibroblasts exhibit diversity and have several subtypes. The underlying relationship between the diversity of cancer-associated fibroblasts and their effect on gastric cancer progression remains unclear. In this study, mesenchymal stem cells were differentiated into cancer-associated fibroblasts with gastric cancer cell lines; clinical specimens were used to further investigate the impact of cancer-associated fibroblast diversity on cancer progression.

methodsNine gastric cancer cell lines (NUGC3, NUGC4, MKN7, MKN45, MKN74, FU97, OCUM1, NCI-N87, and KATOIII) were used to induce mesenchymal stem cell differentiation into cancer-associated fibroblasts. The cancer-associated fibroblasts were classified based on ACTA2 and PDPN expression. Cell function analysis was used to examine the impact of cancer-associated fibroblast subtypes on cancer cell phenotype. Tissue samples from 97gastric patients who underwent gastrectomy were used to examine the clinical significance of each subtype classified according to cancer-associated fibroblast expression.

resultsCo-culture of mesenchymal stem cells with nine gastric cancer cell lines revealed different subtypes of ACTA2 and PDPN expression in differentiated cancer-associated fibroblasts. Cancer-associated fibroblast subtypes with high ACTA2 plus PDPN expression levels significantly increased gastric cancer cell migration, invasion, and proliferation. The cancer-associated fibroblast subtype with ACTA2 plus PDPN expression was an independent prognostic factor along with lymph node metastasis for patients who had gastric cancer and were undergoing surgery.

conclusionsCancer-associated fibroblasts are educated by gastric cancer cells during the development of cancer-associated fibroblast diversity. Differentiated cancer-associated fibroblasts with distinct expression patterns could affect gastric cancer progression and enable prognostic stratification for gastric cancer.

Indexed as

Cancer-Associated FibroblastsStomach NeoplasmsCoculture TechniquesFibroblastsHumansPrognosisCancer-associated fibroblastGastric cancerMicroenvironmentPrognosis

Identifiers

PMID37919449
OpenAlexW4388210301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.