ArticleNature neuroscience2024
Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Transcriptomic analysis of spinal V1 interneurons informs their multifunctional role in motor output.Nature communications · 2026Article
- Distinct transcriptional programs define cranial motor neuron subtypes during vertebrate development.bioRxiv : the preprint server for biology · 2026Article
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Transcriptional profiling of extraocular motor neurons revealsbioRxiv : the preprint server for biology · 2026Article
- Gene expression mapping of conserved GABAergic interneuron markers in developing zebrafish.Frontiers in molecular neuroscience · 2026Article
- Single-cell transcriptomic profiling of zebrafish primary motor neurons reveals subtype-specific gene expression signatures.iScience · 2025Article
- Innovations in spinal cord cell type heterogeneity across vertebrate evolution.bioRxiv : the preprint server for biology · 2025Article
- Supraspinal commands have a modular organization that is behavioral context specific.Current biology : CB · 2025Article
- Separate brainstem circuits for fast steering and slow exploratory turns.Nature communications · 2025Article
- Zebrafish as a model to understand extraocular motor neuron diversity.Current opinion in neurobiology · 2025Review
- The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output.bioRxiv : the preprint server for biology · 2024Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- The Vestibulospinal Nucleus Is a Locus of Balance Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024Article
- The vestibulospinal nucleus is a locus of balance development.bioRxiv : the preprint server for biology · 2024Article
- Multistability of bursting rhythms in a half-center oscillator and the protective effects of synaptic inhibition.Frontiers in cellular neuroscience · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The flexibility of motor actions is ingrained in the diversity of neurons and how they are organized into functional circuit modules, yet our knowledge of the molecular underpinning of motor circuit modularity remains limited. Here we use adult zebrafish to link the molecular diversity of motoneurons (MNs) and the rhythm-generating V2a interneurons (INs) with the modular circuit organization that is responsible for changes in locomotor speed. We show that the molecular diversity of MNs and V2a INs reflects their functional segregation into slow, intermediate or fast subtypes. Furthermore, we reveal shared molecular signatures between V2a INs and MNs of the three speed circuit modules. Overall, by characterizing how the molecular diversity of MNs and V2a INs relates to their function, connectivity and behavior, our study provides important insights not only into the molecular mechanisms for neuronal and circuit diversity for locomotor flexibility but also for charting circuits for motor actions in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.