Evidence map›Paper›PMID 37918924›Full record

ArticleBMJ open2023

Study protocol for a longitudinal observational study of disparities in sleep and cognition in older adults: the DISCO study.

Kristen L Knutson, Mandy L Pershing, Sabra Abbott, Shaina J Alexandria, Sindhu Chiluka, Diana Chirinos, Aida Giachello, Niket Gupta, Katharine Harrington, Sarah S Rittner and 5 more

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristen L KnutsonDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA kristen.knutson@northwestern.edu.ORCID 0000-0002-2751-6168
Mandy L PershingDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-4137-264X
Sabra AbbottDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Shaina J AlexandriaDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sindhu ChilukaDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Diana ChirinosDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Aida GiachelloDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Niket GuptaNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Katharine HarringtonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sarah S RittnerSASU Project Management, Chicago, Illinois, USA.
Farzaneh SorondDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mandy WongDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-3808-2713
Thanh-Huyen T VuDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Phyllis C ZeeDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mercedes R CarnethonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Pathogenic mechanisms of Neuro-PASC in older adultsR01AG059291 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARNETHON, MERCEDES RENEE, KNUTSON, KRISTEN · 2019 to 2023
$4.7M
Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & ResilienceRF1NS085002 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SOROND, FARZANEH A · 2022 to 2022
$1.5M
NCATS NIH HHS UL1 TR001422NIA NIH HHS R01 AG059291NINDS NIH HHS RF1 NS085002
6 · The paper itself

Abstract

introductionCognitive dysfunction, a leading cause of mortality and morbidity in the USA and globally, has been shown to disproportionately affect the socioeconomically disadvantaged and those who identify as black or Hispanic/Latinx. Poor sleep is strongly associated with the development of vascular and metabolic diseases, which correlate with cognitive dysfunction. Therefore, sleep may contribute to observed disparities in cognitive disorders. The Epidemiologic Study of Disparities in Sleep and Cognition in Older Adults (DISCO) is a longitudinal, observational cohort study that focuses on gathering data to better understand racial/ethnic sleep disparities and illuminate the relationship among sleep, race and ethnicity and changes in cognitive function. This investigation may help inform targeted interventions to minimise disparities in cognitive health among ageing adults. METHODS AND ANALYSIS: The DISCO study will examine up to 495 individuals aged 55 and older at two time points over 24 months. An equal number of black, white and Hispanic/Latinx individuals will be recruited using methods aimed for adults traditionally under-represented in research. Study procedures at each time point will include cognitive tests, gait speed measurement, wrist actigraphy, a type 2 home polysomnography and a clinical examination. Participants will also complete self-identified assessments and questionnaires on cognitive ability, sleep, medication use, quality of life, sociodemographic characteristics, diet, substance use, and psychological and social health. ETHICS AND DISSEMINATION: This study was approved by the Northwestern University Feinberg School of Medicine Institutional Review Board. Deidentified datasets will be shared via the BioLINCC repository following the completion of the project. Biospecimen samples from the study that are not being analysed can be made available to qualified investigators on review and approval by study investigators. Requests that do not lead to participant burden or that conflict with the primary aims of the study will be reviewed by the study investigators.

Indexed as

Cognitive DysfunctionQuality of LifeAgedCognitionHumansObservational Studies as TopicSelf ReportSleepdementiaepidemiologygeriatric medicinehealth equitypublic healthsleep medicine

Identifiers

PMID37918924
PMCPMC10626830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.