Evidence map›Paper›PMID 37918635›Full record

ArticleJournal of thrombosis and haemostasis : JTH2024

Development and validation of a risk model for hospital-acquired venous thrombosis: the Medical Inpatients Thrombosis and Hemostasis study.

Neil A Zakai, Katherine Wilkinson, Andrew D Sparks, Ryan T Packer, Insu Koh, Nicholas S Roetker, Allen B Repp, Ryan Thomas, Chris E Holmes, Mary Cushman and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Prognostic Nutritional Index as a Potential Biomarker for the Risk of Lower Extremity Deep Venous Thrombosis: A Large Retrospective Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Neil A ZakaiDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA. Electronic address: Neil.Zakai@med.uvm.edu.
Katherine WilkinsonDepartment of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Andrew D SparksDepartment of Medical Biostatistics, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Ryan T PackerDepartment of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Insu KohDepartment of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; SyllogisTeks, Chesterfield, Missouri, USA.
Nicholas S RoetkerChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Allen B ReppDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA.
Ryan ThomasDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA.
Chris E HolmesDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA.
Timothy B PlanteDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA.
Hanny Al-SamkariDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Allyson M PishkoDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
William A WoodDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Camila MasiasMiami Cancer Institute, Baptist Health South Florida, Coral Gables, Florida, USA.
Radhika GangarajuInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ang LiSection of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, USA.
David GarciaDivision of Hematology, University of Washington School of Medicine, Seattle, Washington, USA.
Kerri L WigginsDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jordan K SchaeferDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Craig HooperDivision of Blood Disorders, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Nicholas L SmithKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, USA; Department of Epidemiology, University of Washington, Seattle, Washington, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA.
Leslie A McClureDepartment of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania, USA.

Funding

Thrombosis and Bleeding Risk Assessment in Medical InpatientsR01HL141290 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Deirdra R Terrell, Neil Adrian Zakai · 2019 to 2026
$3.5M
Clonal Hematopoiesis in a Biracial PopulationK08HL159290 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Radhika Gangaraju · 2022 to 2026
$820k
An Intervention to Reduce Cancer Associated Thrombosis Through Improved ProphylaxisK01HL169920 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jordan Schaefer · 2023 to 2026
$684k
NHLBI NIH HHS K01 HL169920NHLBI NIH HHS K08 HL159290NHLBI NIH HHS R01 HL141290
6 · The paper itself

Abstract

backgroundRegulatory organizations recommend assessing hospital-acquired (HA) venous thromboembolism (VTE) risk for medical inpatients.

objectivesTo develop and validate a risk assessment model (RAM) for HA-VTE in medical inpatients using objective and assessable risk factors knowable at admission.

methodsThe development cohort included people admitted to medical services at the University of Vermont Medical Center (Burlington, Vermont) between 2010 and 2019, and the validation cohorts included people admitted to Hennepin County Medical Center (Minneapolis, Minnesota), University of Michigan Medical Center (Ann Arbor, Michigan), and Harris Health Systems (Houston, Texas). Individuals with VTE at admission, aged <18 years, and admitted for <1 midnight were excluded. We used a Bayesian penalized regression technique to select candidate HA-VTE risk factors for final inclusion in the RAM.

resultsThe development cohort included 60 633 admissions and 227 HA-VTE, and the validation cohorts included 111 269 admissions and 651 HA-VTE. Seven HA-VTE risk factors with t statistics ≥1.5 were included in the RAM: history of VTE, low hemoglobin level, elevated creatinine level, active cancer, hyponatremia, increased red cell distribution width, and malnutrition. The areas under the receiver operating characteristic curve and calibration slope were 0.72 and 1.10, respectively. The areas under the receiver operating characteristic curve and calibration slope were 0.70 and 0.93 at Hennepin County Medical Center, 0.70 and 0.87 at the University of Michigan Medical Center, and 0.71 and 1.00 at Harris Health Systems, respectively. The RAM performed well stratified by age, sex, and race.

conclusionWe developed and validated a RAM for HA-VTE in medical inpatients. By quantifying risk, clinicians can determine the potential benefits of measures to reduce HA-VTE.

Indexed as

ThrombosisVenous ThromboembolismVenous ThrombosisBayes TheoremHospitalsHumansInpatientsRetrospective StudiesRisk AssessmentRisk Factorshospitalizationinpatientsrisk assessmentrisk factorsvenous thrombosis

Identifiers

PMID37918635
PMCPMC10872863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.