ArticleScience (New York, N.Y.)2023
Volitional activation of remote place representations with a hippocampal brain-machine interface.
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026Article
- Article
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- Children and adults can suspend core principles about objects and agents given a small amount of counterevidence on screen.Scientific reports · 2025Article
- From mechanism to applications: Advanced microneedles for clinical medicine.Bioactive materials · 2025Review
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Reveal the mechanism of brain function with fluorescence microscopy at single-cell resolution: from neural decoding to encoding.Journal of neuroengineering and rehabilitation · 2025Review
- Human neural dynamics of real-world and imagined navigation.Nature human behaviour · 2025Article
- Article
- Shaping the Space: A Role for the Hippocampus in Mental Imagery Formation.Vision (Basel, Switzerland) · 2025Review
- Guiding principles and considerations for designing a well-structured curriculum for the brain-computer interface major based on the multidisciplinary nature of brain-computer interface.Frontiers in human neuroscience · 2025Review
- Closed-loop modulation of remote hippocampal representations with neurofeedback.bioRxiv : the preprint server for biology · 2024Article
- Multifunctional human visual pathway-replicated hardware based on 2D materials.Nature communications · 2024Article
- Conjunctive encoding of exploratory intentions and spatial information in the hippocampus.Nature communications · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Tests for learning and memory in rodent regulatory studies.Current research in toxicology · 2024Article
- A Method for Assessing Working Memory in Rats Using Controlled Virtual Environment.Sovremennye tekhnologii v meditsine · 2024Article
- Volitional activation of remote place representations with a hippocampal brain-machine interface.Science (New York, N.Y.) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The hippocampus is critical for recollecting and imagining experiences. This is believed to involve voluntarily drawing from hippocampal memory representations of people, events, and places, including maplike representations of familiar environments. However, whether representations in such "cognitive maps" can be volitionally accessed is unknown. We developed a brain-machine interface to test whether rats can do so by controlling their hippocampal activity in a flexible, goal-directed, and model-based manner. We found that rats can efficiently navigate or direct objects to arbitrary goal locations within a virtual reality arena solely by activating and sustaining appropriate hippocampal representations of remote places. This provides insight into the mechanisms underlying episodic memory recall, mental simulation and planning, and imagination and opens up possibilities for high-level neural prosthetics that use hippocampal representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.