Evidence map›Paper›PMID 37917331›Full record

SynthesisCanadian journal of anaesthesia = Journal canadien d'anesthesie2023

Landiolol for the prevention of postoperative atrial fibrillation after cardiac surgery: a systematic review and meta-analysis.

Teresa Cafaro, Melissa Allwood, William F McIntyre, Lily J Park, Julian Daza, Sandra N Ofori, Michael Ke Wang, Flavia K Borges, David Conen, Maura Marcucci and 7 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Landiolol for the prevention of postoperative atrial fibrillation: a trial sequential analysis.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Teresa CafaroPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada. teresa.cafaro@mcgill.ca.ORCID http://orcid.org/0000-0002-6559-3586
Melissa AllwoodDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
William F McIntyrePopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Lily J ParkDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Julian DazaDivision of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Sandra N OforiPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Michael Ke WangPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Flavia K BorgesPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Maura MarcucciPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Jeff S HealeyPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Richard P WhitlockPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Andre LamyPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Emilie P Belley-CôtéPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Jessica D SpencePopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Michael McGillionPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
P J DevereauxPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Population Health Research Institute · CAMcMaster University · CAJewish General Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. Although the evidence suggests that beta blockers prevent POAF, they often cause hypotension. Landiolol, an ultra-short-acting β SOURCE: We searched MEDLINE, CENTRAL, Embase, and trial registries between January 1970 and March 2022. We included randomized controlled trials (RCTs) that evaluated the effect of landiolol for the prevention of POAF after cardiac surgery. Two reviewers independently assessed eligibility, extracted data, and assessed risk of bias using the Risk of Bias 2.0 tool. We pooled data using random-effects models. We used the Grading of Recommendations, Assessment, Development and Evaluations framework to assess certainty of evidence. PRINCIPAL

findingsNine RCTs including 868 participants met the eligibility criteria. Patients randomized to landiolol (56/460) had less POAF compared with controls (133/408) with a relative risk (RR) of 0.40 (95% confidence interval [CI], 0.30 to 0.54; I

conclusionIn patients undergoing cardiac surgery, landiolol likely reduces POAF and may reduce LOS. A definitive large RCT is needed to confirm these findings. STUDY REGISTRATION: PROSPERO (CRD42021262703); registered 25 July 2021.

Indexed as

Atrial FibrillationCardiac Surgical ProceduresHumansMorpholinesPostoperative ComplicationsRandomized Controlled Trials as TopicUrealandiololMorpholinesUreaatrial fibrillationlandiololPOAFpostoperative

Identifiers

PMID37917331
PMCPMC10656308
OpenAlexW4388219411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.