Evidence map›Paper›PMID 37917280›Full record

ArticleJournal of neuro-oncology2023

Predictors for delayed awakening in adult glioma patients receiving awake craniotomy under monitored anesthesia care.

Huan-Tang Lin, Chun-Ming Lin, Yah-Yuan Wu, Wei-Han Chang, Kuo-Chen Wei, Yi-Chun Chen, Pin-Yuan Chen, Fu-Chao Liu, Ko-Ting Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Huan-Tang LinDepartment of Anesthesiology, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, 333, Taiwan.
Chun-Ming LinDepartment of Anesthesiology, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, 333, Taiwan.
Yah-Yuan WuDepartment of Neurology, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, 333, Taiwan.
Wei-Han ChangDepartment of Physical Medicine & Rehabilitation, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, 333, Taiwan.
Kuo-Chen WeiDepartment of Neurosurgery, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan, Taoyuan, 333, Taiwan.
Yi-Chun ChenDepartment of Neurology, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, 333, Taiwan.
Pin-Yuan ChenDepartment of Neurosurgery, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan, Taoyuan, 333, Taiwan.
Fu-Chao LiuDepartment of Anesthesiology, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, 333, Taiwan.
Ko-Ting ChenDepartment of Neurosurgery, College of Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan, Taoyuan, 333, Taiwan. chenkoting@gmail.com.
Chang Gung University · TWLinkou Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital at Linkou CMRPG3L1001National Science and Technology Council NSTC 112-2314-B-182A-091-MY2
6 · The paper itself

Abstract

purposeDelayed awakening after anesthetic discontinuation during awake craniotomy is associated with somnolence during functional brain mapping. However, predictors of delayed awakening in patients receiving monitored anesthesia care for awake craniotomy are unknown.

methodsThis retrospective cohort study analyzed 117 adult patients with supratentorial glioma in or near eloquent areas who received monitored anesthesia care for awake craniotomy between July 2020 and January 2023 at Linkou Chang Gung Memorial Hospital. These patients were divided into two groups according to their time to awakening (ability to speak their names) after propofol cessation: longer or shorter than 20 min (median duration). Because propofol was solely used anesthetic from skin incision to dural opening, parameters in Schnider model for propofol target-controlled infusion, such as age, sex, and BMI, were adjusted or propensity-matched to compare their anesthetic, surgical, and histopathological profiles.

resultsAfter propensity-matched comparisons of age and BMI, significant predictors of delayed awakening included IDH1 wild-type tumors and repeated craniotomies. Subgroup analysis revealed that older age and larger T2 volume were predictors in patients undergoing the first craniotomy, while lower preoperative Karnofsky performance scale scores and depression were predictors in repeated craniotomy cases. Delayed awakening was also associated with somnolence and a lower gross total resection rate.

conclusionOur retrospective analysis of patients receiving monitored anesthesia care for awake craniotomy revealed that delayed awakening after propofol discontinuation occurred more often in patients with IDH1 wild-type tumors and repeated craniotomies. Also, delayed awakening was associated with somnolence during functional mapping and a lower gross total resection rate.

Indexed as

AnesthesiaAnestheticsBrain NeoplasmsGliomaPropofolAdultCraniotomyHumansRetrospective StudiesSleepinessWakefulnessAnestheticsPropofolAwake craniotomyGliomaIsocitrate dehydrogenaseKarnofsky performance scaleSomnolence

Identifiers

PMID37917280
PMCPMC10689299
OpenAlexW4388231712

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.