ArticleClinical and experimental immunology1986
The density of HLA-DR antigen expression on alveolar macrophages is increased in pulmonary sarcoidosis.
Article in Clinical and experimental immunology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
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- T-cell cytokines may control the balance of functionally distinct macrophage populations.Immunology · 1997Article
- Enrichment and characterization of dendritic cells from human bronchoalveolar lavages.Clinical and experimental immunology · 1994Article
- Targeting of c-myc and beta-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3' untranslated region.The Biochemical journal · 1994Article
- Enhancement of the antigen-presenting function of monocytes by cholesterol: possible relevance to inflammatory mechanisms in extrinsic allergic alveolitis and atherosclerosis.Clinical and experimental immunology · 1992Article
- Article
- Normal and sarcoid alveolar macrophages differ in their ability to present antigen and to cluster with autologous lymphocytes.Clinical and experimental immunology · 1991Article
- Article
- Immunological localization of ribosomes in striated rat muscle. Evidence for myofibrillar association and ontological changes in the subsarcolemmal:myofibrillar distribution.The Biochemical journal · 1990Article
- Article
- Increased expression of HLA-DR antigen on alveolar macrophages in pulmonary diseases.Virchows Archiv. A, Pathological anatomy and histopathology · 1989Article
- Phenotypic and functional changes in alveolar macrophages contribute to the pathogenesis of pulmonary sarcoidosis.Clinical and experimental immunology · 1988Article
- Immune aspects of sarcoidosis.Postgraduate medical journal · 1988Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The density of HLA-DR antigen expression on alveolar macrophages obtained by bronchoalveolar lavage from sarcoidosis patients and normal control subjects was quantified using scanning and integrating microdensitometry in conjunction with a monoclonal mouse anti-human HLA-DR antibody directly conjugated to fungal glucose oxidase. The density of HLA-DR antigen expression on alveolar macrophages was significantly increased in the pulmonary sarcoidosis patients compared with normal control subjects examined. The reproducibility, specificity and sensitivity establish the reliability and potential importance of this method of direct quantification of cell surface antigen expression. The demonstration of an increased density of Class II Major Histocompatibility Complex (MHC) antigen expression on alveolar macrophages in pulmonary sarcoidosis suggests that these cells may play a role in the induction of the immune responses at sites of disease activity in this poorly understood condition.
Indexed as
Identifiers
3791697PMC1542278W205675534What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.