Evidence map›Paper›PMID 37916834›Full record

ArticleJournal of virology2023

Characterization of non-neutralizing human monoclonal antibodies that target the M1 and NP of influenza A viruses.

Willemijn Frederique Rijnink, Daniel Stadlbauer, Eduard Puente-Massaguer, Nisreen M A Okba, Ericka Kirkpatrick Roubidoux, Shirin Strohmeier, Philip A Mudd, Aaron Schmitz, Ali Ellebedy, Meagan McMahon and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Willemijn Frederique Rijnink *Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Daniel Stadlbauer *Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Eduard Puente-MassaguerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Nisreen M A OkbaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Ericka Kirkpatrick RoubidouxDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Shirin StrohmeierDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Philip A MuddDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0002-3860-5473
Aaron SchmitzDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, Missouri, USA.
Ali EllebedyDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, Missouri, USA.
Meagan McMahonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.ORCID 0000-0002-7450-6624
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.ORCID 0000-0003-4121-776X
Icahn School of Medicine at Mount Sinai · USWashington University in St. Louis · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Development of Universal Influenza Virus Vaccines Using Nucleoside-Modified Messenger RNAR01AI146101 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PARDI, NORBERT · 2019 to 2023
$3.1M
NIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93021C00014NIAID NIH HHS HHSN272201400008CNIAID NIH HHS R01 AI146101
6 · The paper itself

Abstract

importanceCurrently, many groups are focusing on isolating both neutralizing and non-neutralizing antibodies to the mutation-prone hemagglutinin as a tool to treat or prevent influenza virus infection. Less is known about the level of protection induced by non-neutralizing antibodies that target conserved internal influenza virus proteins. Such non-neutralizing antibodies could provide an alternative pathway to induce broad cross-reactive protection against multiple influenza virus serotypes and subtypes by partially overcoming influenza virus escape mediated by antigenic drift and shift. Accordingly, more information about the level of protection and potential mechanism(s) of action of non-neutralizing antibodies targeting internal influenza virus proteins could be useful for the design of broadly protective and universal influenza virus vaccines.

Indexed as

Antibodies, MonoclonalInfluenza A virusNucleocapsid ProteinsViral Matrix ProteinsAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza, HumanAntibodies, MonoclonalAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusM1 protein, Influenza A virusNP protein, Influenza A virusNucleocapsid ProteinsViral Matrix Proteinsantibodiesinfluenzamatrix proteinnucleoprotein

Identifiers

PMID37916834
PMCPMC10688359
OpenAlexW4388232998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.