Evidence map›Paper›PMID 37916637›Full record

ReviewCurrent pharmaceutical biotechnology2024

A Review of Cartilage Defect Treatments Using Chitosan Hydrogels in Experimental Animal Models.

Lais Caroline Souza-Silva, Cintia Cristina Santi Martignago, Homero Garcia Motta, Mirian Bonifacio, Ingrid Regina Avanzi, Lívia Assis, Daniel Araki Ribeiro, Julia Risso Parisi, Ana Claudia Rennó

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lais Caroline Souza-SilvaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.ORCID 0000-0002-5246-8356
Cintia Cristina Santi MartignagoDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.ORCID 0000-0003-3980-6354
Homero Garcia MottaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Mirian BonifacioDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Ingrid Regina AvanziDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Lívia AssisScientific and Technological Institute, Brazil University, São Paulo, 08230-030, Brazil.
Daniel Araki RibeiroDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Julia Risso ParisiDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Ana Claudia RennóDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Universidade Federal de São Paulo · BRUniversidade Metropolitana de Santos · BR

Funding

São Paulo Research Foundation 2019/10228-5, 2021/02974-9
6 · The paper itself

Abstract

introductionChitosan (CS) is a polycationic polysaccharide comprising glucosamine and N-acetylglucosamine and constitutes a potential material for use in cartilage tissue engineering. Moreover, CS hydrogels are able to promote the expression of cartilage matrix components and reduce inflammatory and catabolic mediator production by chondrocytes. Although all the positive outcomes, no review has analyzed the effects of CS hydrogels on cartilage repair in animal models.

methodsThis study aimed to review the literature to examine the effects of CS hydrogels on cartilage repair in experimental animal models. The search was done by the descriptors of the Medical Subject Headings (MeSH) defined below: "Chitosan," "hydrogel," "cartilage repair," and "in vivo." A total of 420 articles were retrieved from the databases Pubmed, Scopus, Embase, Lilacs, and Web of Science. After the eligibility analyses, this review reported 9 different papers from the beginning of 2002 through the middle of 2022.

resultsIt was found that cartilage repair was improved with the treatment of CS hydrogel, especially the one enriched with cells. In addition, CS hydrogel produced an upregulation of genes and proteins that act in the cartilage repair process, improving the biomechanical properties of gait..

conclusionIn conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate the process of cartilage repair in animal studies.

Indexed as

ChitosanHydrogelsAnimalsCartilageDisease Models, AnimalHumansModels, AnimalTissue EngineeringChitosanHydrogelscartilage repairchitosanHydrogelin vivo studiesreview.tissue engineering

Identifiers

PMID37916637
OpenAlexW4388223953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.