ArticleNeurourology and urodynamics2024
Sex differences in lower urinary tract function in mice with or without spinal cord injury.
Article in Neurourology and urodynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 10 citations in OpenAlex.
- Impact of Electrical Spinal Cord Stimulation on Lower Urinary Tract Dysfunction in Mice With Spinal Cord Injury.International neurourology journal · 2026Article
- Animal models of spinal cord injury in neuro-urological research.Nature reviews. Urology · 2026Review
- Therapeutic effects of imidazoline 2 receptor activation on lower urinary tract dysfunction in a mouse model of spinal cord injury.American journal of physiology. Renal physiology · 2026Article
- Noninvasive monitoring of lower urinary tract dysfunction in rats with bladder outlet obstruction using uroflowmetry and ultrasonography.International urology and nephrology · 2026Article
- Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney.Frontiers in molecular biosciences · 2026Article
- UROREC: A cystometry and electromyography recording system for analyzing urinary incontinence parameters in rat models.PloS one · 2026Article
- Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus.Physiological reports · 2025Article
- Article
- Sexual Dimorphism of Spinal Neural Circuits Controlling the Mouse External Urethral Sphincter With and Without Spinal Cord Injury.The Journal of comparative neurology · 2024Article
- Ablation of the integrin CD11b mac-1 limits deleterious responses to traumatic spinal cord injury and improves functional recovery in mice.Research square · 2024Article
- Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives.International neurourology journal · 2024Article
- Qualitative and quantitative characterization of the Rhesus monkey (Macaca mulatta) penis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesWe examined sex differences of lower urinary tract function and molecular mechanisms in mice with and without spinal cord injury (SCI).
methodsSCI was induced by Th8-9 spinal cord transection in male and female mice. We evaluated cystometrograms (CMG) and electromyography (EMG) of external urethral sphincter (EUS) at 6 weeks after SCI in spinal intact (SI) and SCI mice. The mRNA levels of Piezo2 and TRPV1 were measured in L6-S1 dorsal root ganglia (DRG). Protein levels of nerve growth factor (NGF) in the bladder mucosa was evaluated using an enzyme-linked immunosorbent assay.
resultsSex differences were found in the EUS behavior during voiding as voiding events in female mice with or without SCI occurred during EUS relaxation periods without EUS bursting activity whereas male mice with or without SCI urinated during EUS bursting activity in EMG recordings. In both sexes, SCI decreased voiding efficiency along with increased tonic EUS activities evident as reduced EUS relaxation time in females and longer active periods of EUS bursting activity in males. mRNA levels of Piezo2 and TRPV1 of DRG in male and female SCI mice were significantly upregulated compared with SI mice. NGF in the bladder mucosa showed a significant increase in male and female SCI mice compared with SI mice. However, there were no significant differences in Piezo2 or TRPV1 levels in DRG or NGF protein levels in the bladder mucosa between male and female SCI mice.
conclusionsWe demonstrated that female and male mice voided during EUS relaxation and EUS bursting activity, respectively. Also, upregulation of TRPV1 and Piezo2 in L6-S1 DRG and NGF in the bladder could be involved in SCI-induced lower urinary tract dysfunction in both sexes of mice.
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