ArticleExperimental biology and medicine (Maywood, N.J.)2023
Effect of smoking on the redox status of knee osteoarthritis: A preliminary study.
Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- The Role of Myeloperoxidase in Osteoarthritis and Its Potential Modulation by Resveratrol: An Integrated Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Cigarette Smoke Extract Alters the Inflammatory Secretome of Osteoarthritis-Affected Synovium Increasing Joint Tissue Oxidative Stress in an Indirect Co-Culture Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- A cross-sectional study unveiling the global impact and future projections through 2060 of osteoarthritis.European journal of public health · 2026Article
- Cigarette and Electronic Cigarette Exposure in Osteoarthritis: Immune Dysregulation and Inflammatory Signaling Pathways.International journal of general medicine · 2026Article
- Vascular clues in joint degeneration: a cross-sectional study on the association between aortic knob width, aortic arch calcification, and the severity of hand and knee osteoarthritis.BMC musculoskeletal disorders · 2025Article
- Relationship between cardiovascular health and osteoarthritis in middle-aged and elderly U.S. population: a cross-sectional NHANES study.BMC musculoskeletal disorders · 2025Article
- Assessing the impact of tobacco smoke exposure on earlyonset osteoarthritis: A cross-sectional analysis of secondary data from the National Health and Nutrition Examination Survey (NHANES), 1999-2020.Tobacco induced diseases · 2025Article
- The causal impact of smoking behavior on osteoarthritis: a Mendelian randomization analysis.Frontiers in public health · 2025Article
- Adverse childhood experiences and arthritis risk: exploring behavioral and psychological mediators in the behavioral risk factor surveillance system.Frontiers in public health · 2025Article
- Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis.Journal of orthopaedic translation · 2024Review
- An improved method for measuring catalase activity in biological samples.Biology methods & protocols · 2024Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though smoking has been scarcely studied in osteoarthritis (OA) etiology, it is considered a controversial risk factor for the disease. Exposure to tobacco smoke has been reported to promote oxidative stress (OS) as part of the damage mechanism. The aim of this study was to assess whether smoking increases cartilage damage through the generation of OS. Peripheral blood (PB) and synovial fluid (SF) samples from patients with OA were analyzed. The samples were stratified according to smoking habit, Kellgren-Lawrence score, pain, and cotinine concentrations in PB. Malondialdehyde (MDA), methylglyoxal (MGO), advanced protein oxidation products (APOPs), and myeloperoxidase (MPO) were assessed; the activity of antioxidant enzymes such as gamma-glutamyl transferase (GGT), glutathione S-transferase (GST) and catalase (CAT), as well as the activity of arginase, which favors the destruction of cartilage, was determined. When stratified by age, for individuals <60 years, the levels of MDA and APOPs and the activity of MPO and GST were higher, as well as antioxidant system activity in the smoking group (OA-S). A greater degree of pain in the OA-S group increased the concentrations of APOPs and arginase activity (
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