Evidence map›Paper›PMID 37916299›Full record

ArticleLab on a chip2023

Driving electrochemical reactions at the microscale using CMOS microelectrode arrays.

Jens Duru, Arielle Rüfenacht, Josephine Löhle, Marcello Pozzi, Csaba Forró, Linus Ledermann, Aeneas Bernardi, Michael Matter, André Renia, Benjamin Simona and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Jens DuruLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Arielle RüfenachtLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Josephine LöhleLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Marcello PozziLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Csaba ForróLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Linus LedermannLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Aeneas BernardiLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Michael MatterLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
André ReniaLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Benjamin SimonaEctica Technologies AG, Zürich, Switzerland.
Christina M TringidesLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Stéphane BernhardMacromolecular Engineering Laboratory, Department of Mechanical and Process Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland.
Stephan J IhleLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Julian HengstelerLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Benedikt MaurerLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Xinyu ZhangLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.
Nako NakatsukaLaboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland. nakatsuka@biomed.ee.ethz.ch.ORCID http://orcid.org/0000-0001-8248-5248
ETH Zurich · CHBoard of the Swiss Federal Institutes of Technology · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise control of pH values at electrode interfaces enables the systematic investigation of pH-dependent processes by electrochemical means. In this work, we employed high-density complementary metal-oxide-semiconductor (CMOS) microelectrode arrays (MEAs) as miniaturized systems to induce and confine electrochemical reactions in areas corresponding to the pitch of single electrodes (17.5 μm). First, we present a strategy for generating localized pH patterns on the surface of the CMOS MEA with unprecedented spatial resolution. Leveraging the versatile routing capabilities of the switch matrix beneath the CMOS MEA, we created arbitrary combinations of anodic and cathodic electrodes and hence pH patterns. Moreover, we utilized the system to produce polymeric surface patterns by additive and subtractive methods. For additive patterning, we controlled the

Identifiers

PMID37916299
PMCPMC10661664
OpenAlexW4388075414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.