Evidence map›Paper›PMID 37916184›Full record

ArticleGeburtshilfe und Frauenheilkunde2023

Update Breast Cancer 2023 Part 2 - Advanced-Stage Breast Cancer.

Michael P Lux, Andreas D Hartkopf, Tanja N Fehm, Manfred Welslau, Volkmar Müller, Florian Schütz, Peter A Fasching, Wolfgang Janni, Isabell Witzel, Christoph Thomssen and 20 more

Open access · hybridAbstract read
In one paragraph

Article in Geburtshilfe und Frauenheilkunde, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 3 countries.

Michael P LuxKlinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany.
Andreas D HartkopfDepartment of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany.
Tanja N FehmDepartment of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany.
Manfred WelslauOnkologie Aschaffenburg, Aschaffenburg, Germany.
Volkmar MüllerDepartment of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany.
Florian SchützGynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany.
Peter A FaschingErlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Wolfgang JanniDepartment of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany.
Isabell WitzelKlinik für Gynäkologie, Universitätsspital Zürich, Zürich, Switzerland.
Christoph ThomssenDepartment of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Milena BeierleinErlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Erik BellevilleClinSol GmbH & Co KG, Würzburg, Germany.
Michael UntchClinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany.
Marc ThillDepartment of Gynecology and Gynecological Oncology, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany.
Hans TeschOncology Practice at Bethanien Hospital, Frankfurt am Main, Germany.
Nina DitschDepartment of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany.
Bahriye AktasDepartment of Gynecology, University of Leipzig Medical Center, Leipzig, Germany.
Maggie Banys-PaluchowskiDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Cornelia Kolberg-LiedtkeDepartment of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.
Achim WöckelDepartment of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany.
Hans-Christian KolbergDepartment of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany.
Nadia HarbeckBreast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, München, Germany.
Rupert BartschDepartment of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.
Andreas SchneeweissNational Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany.
Johannes EttlKlinik für Frauenheilkunde und Gynäkologie, Klinikum Kempten, Klinikverbund Allgäu, Kempten, Germany.
Rachel WürstleinBreast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, München, Germany.
David KrugKlinik für Strahlentherapie, Universitätsklinkum Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Florin-Andrei TaranDepartment of Gynecology and Obstetrics, University Hospital Freiburg, Freiburg, Germany.
Diana LüftnerMedical University of Brandenburg Theodor-Fontane, Immanuel Hospital Märkische Schweiz, Buckow, Germany.
Elmar StickelerDepartment of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany.
Comprehensive Cancer Center Erlangen · DELudwig-Maximilians-Universität München · DEUniversity Hospital Ulm · DEAgaplesion Markus Hospital · DECardiovascular Center Bethanien · DEDiakonissenkrankenhaus · DEDüsseldorf University Hospital · DEEssen University Hospital · DEGerman Cancer Research Center · DEHeinrich Heine University Düsseldorf · DEHelios Hospital Berlin-Buch · DEKempten University of Applied Sciences · DEKlinikum Aschaffenburg · DELeipzig University · DEMarienhospital Bottrop · DEMartin Luther University Halle-Wittenberg · DEMedical University of Vienna · ATUniversitätsklinik für Strahlentherapie · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a number of new therapies have led to advances in the treatment of patients with advanced breast carcinoma. These substances are mainly CDK4/6 inhibitors and other substances that can overcome endocrine resistance, oral selective estrogen receptor degraders, antibody drug conjugates (ADCs), and PARP inhibitors. This review summarizes and evaluates the latest study results that have been published in recent months. This includes the overall survival data of the Destiny-Breast03 study, the first analysis of the CAPItello-291 study, the comparison of CDK4/6 inhibitor treatment with chemotherapy in the first line of therapy (RIGHT Choice study), the first analysis of the Destiny-Breast02 study in the treatment setting after T-DM1 treatment, and the first analysis of the Serena-2 study. Most of these studies have the potential to significantly change the therapeutic landscape for patients with advanced breast carcinoma and show that the continued rapid development of new therapies is always producing new results.

Indexed as

antibody drug conjugatebreast cancerchemotherapyendocrine therapymetastatic

Identifiers

PMID37916184
PMCPMC10617389
OpenAlexW4379537117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.