Evidence map›Paper›PMID 37915955›Full record

ArticleThe World Allergy Organization journal2023

Global disparities in availability of epinephrine auto-injectors.

Luciana Kase Tanno, Margitta Worm, Motohiro Ebisawa, Ignacio J Ansotegui, Gianenrico Senna, Stanley Fineman, Mario Geller, Alexei Gonzalez-Estrada, Dianne E Campbell, Agnes Leung and 21 more

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Health inequities in pediatric anaphylaxis: A policy framework and call to action for equitable care from SIAIP allergy prevention commission.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Food Allergy in Children in China.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Review
  12. First-in-class intranasal epinephrine spray for anaphylaxis: Dose finding clinical study.The journal of allergy and clinical immunology. Global · 2025
    Article
  13. Article
  14. Review
  15. Alternatives to Injectable Adrenaline for Treating Anaphylaxis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Review
  16. Adrenaline Auto-Injectors for Preventing Fatal Anaphylaxis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 18 countries.

Luciana Kase TannoDivision of Allergy, Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France.
Margitta WormAllergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Campus Charité Mitte, Universitätsmedizin Berlin, Germany.
Motohiro EbisawaClinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
Ignacio J AnsoteguiDepartment of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
Gianenrico SennaDepartment of Medicine, Allergy Asthma and Clinical Immunology Section, University of Verona, Verona, Italy.
Stanley FinemanAtlanta Allergy & Asthma, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Mario GellerSection of Medicine of the Brazilian Academy of Medicine of Rio de Janeiro, Rio de Janeiro, Brazil.
Alexei Gonzalez-EstradaDivision of Allergy, Asthma and Clinical Immunology, Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Dianne E CampbellThe University of Sydney, New South Wales, Australia.
Agnes LeungThe Chinese University of Hong Kong, Department of Pediatrics, Prince of Wales Hospital, Hong Kong Special Administrative Region of China.
Antonella MuraroDepartment of Mother and Child Health University of Padua Padua, Italy.
Michael LevinDivision of Paediatric Allergology, University of Cape Town, Cape Town, South Africa.
Jose Antonio Ortega MartellDepartment of Immunology, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico.
Marco CaminatiDepartment of Medicine, University of Verona, Verona, Italy.
Pavel KolkhirInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Duy Le PhamFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet nam.
Razvigor DarlenskiDepartment of Dermatology and Venereology, Acibadem City Clinic Tokuda Hospital Sofia, 51B Nikola Vaptsarov Blvd., 1407, Sofia, Bulgaria.
Ignacio Esteban-GorgojoDepartment of Allergy, Hospital General de Villalba, Madrid, Spain.
Manuel RialAllergology Section, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.
Ivana FilipovicUniversity Hospital Dr Dragisa Misovic, Serbia.
Sergio E ChiarellaDivision of Allergic Diseases, Mayo Clinic, Rochester, MN, USA.
Lyda Cuervo-PardoDivision of Rheumatology, Allergy and Clinical Immunology, Department of Medicine, University of Florida, USA.
Christina KwongPhoenix Children's Hospital, Phoenix, AZ, USA.
Cezar Fireth Pozo-BeltranHospital Infantil de México Federico Gómez, Mexico.
Tu Hk TrinhCenter for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet nam.
Paul A GreenbergerDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA.
Paul J TurnerNational Heart & Lung Institute, Imperial College London, London, UK.
Bernard Yu-Hor ThongDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore.
Bryan MartinMedicine and Pediatrics, The Ohio State University in Columbus, Ohio, USA.
Victoria CardonaAllergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, and ARADyAL Research Network, Spain.
WAO Anaphylaxis Committee and the WAO Junior Members Steering Group
University of Medicine and Pharmacy at Ho Chi Minh City · VNUniversity of Verona · ITAtlanta Allergy and Asthma Clinic · USBrazilian Academy of Sciences · BRCharité - Universitätsmedizin Berlin · DEChinese University of Hong Kong · HKComplexo Hospitalario Universitario A Coruña · ESENT and Allergy · USHebron University · PSHospital Infantil de México Federico Gómez · MXHospital Quirónsalud Barcelona · ESHumboldt-Universität zu Berlin · DEImperial College London · GBInserm · FRMayo Clinic in Arizona · USMayo Clinic in Florida · USNational Sagamihara Hospital · JPNorthwestern University · USPhoenix Children's Hospital · USTan Tock Seng Hospital · SG

Funding

Medical Research Council MR/W018616/1
6 · The paper itself

Abstract

Background: Anaphylaxis is the most severe clinical presentation of acute systemic allergic reactions and can cause death. Given the prevalence of anaphylaxis within healthcare systems, it is a high priority public health issue. However, management of anaphylaxis - both acute and preventative - varies by region. Methods: The World Allergy Organization (WAO) Anaphylaxis Committee and the WAO Junior Members Steering Group undertook a global online survey to evaluate local practice in the diagnosis and management of anaphylaxis across regions. Results: Responses were received from WAO members in 66 countries. While intramuscular epinephrine (adrenaline) is first-line treatment for anaphylaxis, some countries continue to recommend alternative routes in contrast to guidelines. Epinephrine auto-injector (EAI) devices, prescribed to individuals at ongoing risk of anaphylaxis in the community setting, are Conclusion: This survey provides a global snapshot view of the current management of anaphylaxis, and highlights key unmet needs including the global availability of epinephrine for self-injection as a key component of anaphylaxis management.

Indexed as

AdrenalineAdrenaline auto-injectorAnaphylaxisEpinephrine auto-injectorManagementSurveyTreatmentWorld allergy organization (WAO)

Identifiers

PMID37915955
PMCPMC10616381
OpenAlexW4387815155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.