ArticleClinical kidney journal2023
Effect of serum creatinine difference between the Jaffe and the enzymatic method on kidney disease detection and staging.
Article in Clinical kidney journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- [Recommendations for the Diagnosis and Treatment of Chronic Kidney Disease (CKD) by the Austrian Society of Nephrology].Wiener klinische Wochenschrift · 2025Guideline
- Impact of Adherence to a Plant-Based Residential Lifestyle Medicine Program on Cardiometabolic Disease Risk Factors.Nutrients · 2026Observational
- Strengthening the interpretation of longitudinal EQA data through the sporadic inclusion of native human sera in general clinical chemistry.Frontiers in molecular biosciences · 2026Article
- Exploring Therapeutic Potential ofCurrent topics in medicinal chemistry · 2026Article
- Metformin interferes with urinary creatinine measurement using enzymatic method.Biochemistry and biophysics reports · 2025Article
- Article
- Risk Factor-Based Screening for Early Detection of Chronic Kidney Disease in Primary Care Settings: A Systematic Review.Kidney medicine · 2025Article
- Impact of interlaboratory differences on the measurement of serum creatinine and symmetric dimethylarginine values: does this affect clinical decision-making?Journal of feline medicine and surgery · 2025Article
- The Patient and Treatment Characteristics of Kidney Transplant Recipients with a Clinically Relevant Jaffe/Enzymatic Serum Creatinine Difference.Journal of clinical medicine · 2025Article
- Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion.Frontiers in endocrinology · 2025Article
- Using primary and routinely collected data to determine prevalence and patterns of multimorbidity in rural China: a representative cross-sectional study of 6474 Chinese adults.The Lancet regional health. Western Pacific · 2025Article
- Immunosuppression and transplantation-related characteristics affect the difference between eGFR equations based on creatinine compared to cystatin C in kidney transplant recipients.Clinical kidney journal · 2024Article
- Effect of Difference in Serum Creatinine between Jaffe and Enzymatic Methods in Outpatient Kidney Transplant Recipients.Journal of clinical medicine · 2024Article
- Dopamine infusion at typical infusion rates does not cause interference on plasma creatinine assays.Practical laboratory medicine · 2024Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Serum creatinine (SCr), mainly determined by the Jaffe or an enzymatic method, is the central marker to assess kidney function. Deviations between these two methods may affect the diagnosis and staging of acute kidney injury (AKI) and chronic kidney disease (CKD). Methods: The results of the first parallel SCr measurement (Jaffe and enzymatic method) of adult in- and outpatients in the same serum sample at the University Hospital Essen (Essen, Germany) between 2020-2022 were retrospectively evaluated. A Bland-Altman plot with 95% limits of agreement (LoAs) was used to assess the difference between the Jaffe and the enzymatic SCr (eSCr) method. We used the 2009 Chronic Kidney Disease Epidemiology Collaboration equation for determination of estimated glomerular filtration rate (eGFR) according to the Kidney Disease: Improving Global Outcomes guidelines. Results: A total of 41 144 parallel SCr measurements were evaluated. On average, Jaffe SCr was 0.07 mg/dl higher than eSCr (LoA -0.12; 0.25 mg/dl). In 19% of all cases there was a different CKD stage when comparing eGFR between both SCr methods, of which 98% resulted in a more severe CKD stage determined with Jaffe SCr. In 1.6% of all cases Jaffe SCr was ≥0.3 mg/dl higher than eSCr. Conclusion: The present study showed that methods of SCr measurement may affect both the diagnosis and staging of AKI and CKD. This must be taken into account when interpreting measurements of renal function in everyday clinical practice, but also when planning and comparing studies on renal diseases. One should therefore stay with one method for SCr measurement, preferably with the enzymatic method.
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