Evidence map›Paper›PMID 37915883›Full record

ArticleNew journal of chemistry = Nouveau journal de chimie2023

Oligonucleotide synthesis under mild deprotection conditions.

Komal Chillar, Adikari M D N Eriyagama, Yipeng Yin, Shahien Shahsavari, Bhaskar Halami, Alexander Apostle, Shiyue Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in New journal of chemistry = Nouveau journal de chimie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. GuanineOrganic & biomolecular chemistry · 2026
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Komal ChillarDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Adikari M D N EriyagamaDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Yipeng YinDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Shahien ShahsavariDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Bhaskar HalamiDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Alexander ApostleDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Shiyue FangDepartment of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.

Funding

Synthesis of Sensitive Epitranscriptomically Modified RNAsR15GM109288 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI FANG, SHIYUE · 2014 to 2024
$1.3M
NIGMS NIH HHS R15 GM109288
6 · The paper itself

Abstract

Over a hundred non-canonical nucleotides have been found in DNA and RNA. Many of them are sensitive toward nucleophiles. Because known oligonucleotide synthesis technologies require nucleophilic conditions for deprotection, currently there is no suitable technology for their synthesis. The recently disclosed method regarding the use of 1,3-dithian-2-yl-methyl (Dim) for phosphate protection and 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) for amino protection can solve the problem. With Dim-Dmoc protection, oligodeoxynucleotide (ODN) deprotection can be achieved with NaIO

Identifiers

PMID37915883
PMCPMC10617641

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.