Evidence map›Paper›PMID 37915779›Full record

ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2023

Incidences of steroid-induced diabetes mellitus and congestive heart failure in cats given non-immunosuppressive doses of methylprednisolone acetate: 1042 cats.

Wendy A Dutch, Gary D Norsworthy, Milton R Mayfield, Jacqueline R Mayfield, Connie W Schmitt

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Feline immune-mediated skin disorders: Part 1.Journal of feline medicine and surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wendy A DutchAlamo Feline Health Center, 16201 San Pedro Avenue, San Antonio, Texas 78232, USA (Dutch, Norsworthy); Texas A&M International University, 2101 Peach Blossom Street, San Antonio, Texas 78247, USA (M.R. Mayfield, J.R. Mayfield); Texas Veterinary Pathology, 1007 Wagon Wheel, Spring Branch, Texas 78070, USA (Schmitt).
Gary D NorsworthyAlamo Feline Health Center, 16201 San Pedro Avenue, San Antonio, Texas 78232, USA (Dutch, Norsworthy); Texas A&M International University, 2101 Peach Blossom Street, San Antonio, Texas 78247, USA (M.R. Mayfield, J.R. Mayfield); Texas Veterinary Pathology, 1007 Wagon Wheel, Spring Branch, Texas 78070, USA (Schmitt).
Milton R MayfieldAlamo Feline Health Center, 16201 San Pedro Avenue, San Antonio, Texas 78232, USA (Dutch, Norsworthy); Texas A&M International University, 2101 Peach Blossom Street, San Antonio, Texas 78247, USA (M.R. Mayfield, J.R. Mayfield); Texas Veterinary Pathology, 1007 Wagon Wheel, Spring Branch, Texas 78070, USA (Schmitt).
Jacqueline R MayfieldAlamo Feline Health Center, 16201 San Pedro Avenue, San Antonio, Texas 78232, USA (Dutch, Norsworthy); Texas A&M International University, 2101 Peach Blossom Street, San Antonio, Texas 78247, USA (M.R. Mayfield, J.R. Mayfield); Texas Veterinary Pathology, 1007 Wagon Wheel, Spring Branch, Texas 78070, USA (Schmitt).
Connie W SchmittAlamo Feline Health Center, 16201 San Pedro Avenue, San Antonio, Texas 78232, USA (Dutch, Norsworthy); Texas A&M International University, 2101 Peach Blossom Street, San Antonio, Texas 78247, USA (M.R. Mayfield, J.R. Mayfield); Texas Veterinary Pathology, 1007 Wagon Wheel, Spring Branch, Texas 78070, USA (Schmitt).
Texas A&M International University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Corticosteroids are indicated to treat many feline diseases. However, side effects are a limiting factor in their use. The most concerning side effects are steroid-induced diabetes mellitus (SI-DM) and steroid-induced congestive heart failure (SI-CHF). This study aims to determine the incidences of these diseases in a large population of domestic cats seen at a privately-owned, feline-only practice. Animals: Cats in the study were client-owned patients of Alamo Feline Health Center in San Antonio, Texas. Control cats (controls) were examined as part of their routine health care. Procedures: The records of 732 cats that received methylprednisolone acetate (MPA) for various clinical indications were reviewed to determine how many developed SI-DM and SI-CHF. A similar record review of 310 controls was made to determine the incidence of spontaneous diabetes mellitus (Sp-DM) and spontaneous congestive heart failure (Sp-CHF). Control cats never received any oral or injectable corticosteroids. Results: Of the cats that received MPA, 28 developed SI-DM (3.83%) and 6 developed SI-CHF (0.82%). Of the controls, 22 developed Sp-DM (7.10%) and 6 developed Sp-CHF (1.90%). Conclusion: The incidences of developing SI-DM and SI-CHF were 3.83% and 0.82%, respectively; and the risk was not increased even when repeated doses of MPA were given. Clinical relevance: The authors consider the risk-benefit ratio sufficient to justify the use of MPA when it is indicated, especially if another drug cannot be substituted with the same therapeutic results.

Indexed as

Cat DiseasesDiabetes MellitusHeart FailureAdrenal Cortex HormonesAnimalsCatsIncidenceMethylprednisolone AcetateAdrenal Cortex HormonesMethylprednisolone Acetate

Identifiers

PMID37915779
PMCPMC10581361
OpenAlexW4388238483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.