ReviewThe Canadian veterinary journal = La revue veterinaire canadienne2023
Anesthesia update - Incorporating methadone into companion animal anesthesia and analgesic protocols: A narrative review.
Review in The Canadian veterinary journal = La revue veterinaire canadienne, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 5 citations in OpenAlex.
- Intraoperative opioid-sparing effect of a quadratus lumborum block using low-concentration bupivacaine and dexmedetomidine in cats undergoing ovariohysterectomy.Journal of feline medicine and surgery · 2026Article
- Review
- Sedative and anesthetic-sparing effects of perioperative full-spectrum cannabis oil in female dogs undergoing unilateral mastectomy and ovariohysterectomy.Veterinary research communications · 2026Article
- Multimodal Analgesia Provides Superior Postoperative Pain Control Following Orthopedic Surgery in Small-Breed Dogs.Animals : an open access journal from MDPI · 2026Article
- Use of gastric residual volume measured by nasogastric feeding tubes for management of dogs and cats after gastrointestinal foreign body surgery: a retrospective study.Frontiers in veterinary science · 2026Article
- Perioperative drug management in non-critical companion animals: a retrospective study at a Spanish veterinary teaching hospital (2018-2022).The veterinary quarterly · 2025Article
- Use of a novel subcutaneous injection site in the region of acupuncture point GV20 for premedicating cats before general anesthesia.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Perioperative analgesic management using bilateral ultrasound-guided lateral quadratus lumborum block in a dog with extrahepatic biliary obstruction.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opioid analgesics are routinely used during the perioperative period, to provide analgesia and reduce anesthetics doses required to maintain a surgical plane of anesthesia in companion animals. Acting on receptors in the brain, spinal cord, and peripheral nervous system, opioids provide reliable and consistent analgesia; however, they are not without adverse effects. Methadone, a mu agonist opioid analgesic, was recently licensed for veterinary use in Canada. In addition to its action on opioid receptors, methadone contributes to analgesia through other pathways, including inhibition of N-methyl-D-aspartate (NMDA) receptors. It has physiologic effects similar to other mu opioid agents, but fewer adverse gastrointestinal effects. This review discusses methadone's mechanism of action, pharmacologic characteristics, and clinical effects in dogs and cats. Current recommendations for using methadone in companion animals are also provided.
Indexed as
Identifiers
37915778PMC10581351W4388238001What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.