ArticleAnnals of medicine and surgery (2012)2023
Diagnostic challenges in tuberculous meningitis: a case report with negative genexpert result.
Article in Annals of medicine and surgery (2012), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Cerebral tuberculoma in pregnancy (Jan 1975-May 2025): a systematic review and descriptive analysis of 33 published cases.BMC infectious diseases · 2026Pooled it
- Tuberculous Meningitis in Pediatric Patients: Diagnosis, Clinical Course, and Outcomes in the Modern Era.Pathogens (Basel, Switzerland) · 2026Observational
- Advances in management and treatment of tubercular meningitis - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Prolonged Corticosteroid Use in the Treatment of Tuberculous Meningoencephalitis: A Case Report.Medicina (Kaunas, Lithuania) · 2025Article
- Confirmation of Tuberculous Meningitis Using Metagenomic Next-Generation Sequencing: A Case Report.Infection and drug resistance · 2025Article
- A Rare Case of Wolfram Syndrome Presenting With Tuberculous Meningitis: A Case Report.Clinical case reports · 2025Article
- Diagnostic challenge: a case report of primary breast tuberculosis mimicking recurrent pyogenic breast abscess.Annals of medicine and surgery (2012) · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Tuberculous meningitis (TBM) is a severe form of tuberculosis affecting the meninges, primarily caused by Case presentation: The authors report a case of a 22-year-old female from Eastern Nepal presenting with acute-onset fever, headache, vomiting, and neck pain. Cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis, elevated protein, low glucose levels, and cobweb coagulum indicative of TBM. However, the GeneXpert test revealed negative results. Discussion: In resource-limited settings like Nepal, where access to GeneXpert MTB/Rif is limited, CSF analysis and clinical algorithms play a crucial role in diagnosing TBM. Relying solely on GeneXpert results may lead to false negatives, so a high level of suspicion based on patient risk factors is essential. Prompt initiation of empirical antitubercular therapy is vital for a favorable outcome in TBM cases. Conclusion: Negative MTB PCR results from CSF can be misleading in diagnosis of tubercular meningitis. Therefore, comprehensive evaluations, including detailed patient history, physical examination, and CSF fluid analysis, are crucial in high tuberculous prevalence countries to ensure accurate and timely diagnosis.
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Registered trials
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