Evidence map›Paper›PMID 37915599›Full record

ArticleiScience2023

Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE.

Paola Bianchimano, Kacper Iwanowski, Emma M Smith, Adam Cantor, Paola Leone, Gerold Bongers, Carlos G Gonzalez, Yoon Hongsup, Joshua Elias, Howard L Weiner and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Gut Microbiome in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Review
  2. Article
  3. Colonization byFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Paola BianchimanoDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kacper IwanowskiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emma M SmithDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adam CantorPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Paola LeoneDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gerold BongersPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carlos G GonzalezDepartment of Pharmacology, University of California San Diego, San Diego, CA 92093, USA.
Yoon HongsupInstitute of Clinical Neuroimmunology, Hospital and Biomedical Center of the Ludwig-Maximilian-University, Martinsried, Germany.
Joshua EliasMass Spectrometry Platform, Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Howard L WeinerAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Jose C ClementePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephanie K TankouDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USBrigham and Women's Hospital · USChan Zuckerberg Initiative (United States) · USMax Planck Institute of Neurobiology · DEUniversity of California San Diego · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Gut Microbiota in Patients with Multiple SclerosisR01NS087226 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI WEINER, HOWARD L · 2014 to 2018
$1.9M
NIGMS NIH HHS K12 GM068524NINDS NIH HHS R01 NS087226
6 · The paper itself

Abstract

Studies have reported increased intestinal permeability in multiple sclerosis (MS) patients and its mouse model experimental autoimmune encephalomyelitis (EAE). However, the mechanisms driving increased intestinal permeability that in turn exacerbate neuroinflammation during EAE remain unclear. Here we showed that vancomycin preserved the integrity of the intestinal barrier, while also suppressing gut trypsin activity, enhancing the relative abundance of specific

Indexed as

DrugsHuman physiologyMicrobiome

Identifiers

PMID37915599
PMCPMC10616394
OpenAlexW4387358606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.