Evidence map›Paper›PMID 37915594›Full record

ArticleiScience2023

MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology.

Adriana Psaraki, Dimitra Zagoura, Lydia Ntari, Manousos Makridakis, Christina Nikokiraki, Ourania Trohatou, Konstantina Georgila, Christos Karakostas, Ioanna Angelioudaki, Anastasios G Kriebardis and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Adriana PsarakiLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Dimitra ZagouraLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Lydia NtariLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Manousos MakridakisBiotechnology Laboratory, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece.
Christina NikokirakiLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Ourania TrohatouLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Konstantina GeorgilaLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Christos KarakostasLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Ioanna AngelioudakiLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Anastasios G KriebardisLaboratory of Reliability and Quality Control in Laboratory Hematology (HemQcR), Department of Biomedical Sciences, Section of Medical Laboratories, School of Health & Caring Sciences, University of West Attica (UniWA), Ag. Spyridonos Str, 12243 Egaleo, Greece.
Roberto GramignioliClinical Pathology and Cancer Diagnosis Unit, Karolinska Institute, 141 57 Huddinge, Sweden.
Stratigoula SakellariouFirst Department of Pathology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Maria XilouriCenter of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece.
Aristides G EliopoulosLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
Antonia VlahouBiotechnology Laboratory, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece.
Maria G RoubelakisLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
National and Kapodistrian University of Athens · GRBiomedical Research Foundation of the Academy of Athens · GRKarolinska Institutet · SEUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver transplantation is the gold-standard therapy for acute hepatic failure (AHF) with limitations related to organ shortage and life-long immunosuppressive therapy. Cell therapy emerges as a promising alternative to transplantation. We have previously shown that IL-10 and Annexin-A1 released by amniotic fluid human mesenchymal stromal cells (AF-MSCs) and their hepatocyte progenitor-like (HPL) or hepatocyte-like (HPL) cells induce liver repair and downregulate systemic inflammation in a CCl

Indexed as

Biological sciencesCell biologyMolecular biologyStem cells research

Identifiers

PMID37915594
PMCPMC10616317
OpenAlexW4387211361

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.