Evidence map›Paper›PMID 37915502›Full record

ArticleTherapeutic advances in neurological disorders2023

Corneal immune cells as a biomarker of inflammation in multiple sclerosis: a longitudinal study.

Ioannis N Petropoulos, Karen John, Fatima Al-Shibani, Georgios Ponirakis, Adnan Khan, Hoda Gad, Ziyad R Mahfoud, Heba Altarawneh, Muhammad Hassan Rehman, Dhabia Al-Merekhi and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in neurological disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 2 countries.

Ioannis N PetropoulosDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Karen JohnDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Fatima Al-ShibaniDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Georgios PonirakisDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Adnan KhanDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Hoda GadDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Ziyad R MahfoudDivision of Medical Education, Weill Cornell Medicine, Doha, Qatar.
Heba AltarawnehDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Muhammad Hassan RehmanDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Dhabia Al-MerekhiDivision of Research, Weill Cornell Medicine, Doha, Qatar.
Pooja GeorgeNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Faiza IbrahimNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Reny FrancisNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Beatriz CanibanoNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Dirk DeleuNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Ahmed El-SotouhyNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Surjith VattothNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Mark StettnerDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-8836-0443
Ahmed OwnNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Ashfaq ShuaibNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Naveed AkhtarNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Saadat KamranNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0002-0260-2086
Rayaz A MalikWeill Cornell Medicine-Qatar of Cornell University, Research Division, Qatar Foundation, Education City, Al-Luqta street, Doha 24144, Qatar.ORCID https://orcid.org/0000-0002-7188-8903
Hamad Medical Corporation · QAWeill Cornell Medical College in Qatar · QACornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Corneal immune cells (ICs) are antigen-presenting cells that are known to increase ocular and systemic inflammatory conditions. Objective: We aimed to assess longitudinal changes in corneal IC in patients with multiple sclerosis (MS) and relation to disability and ongoing treatment. Design: Prospective observational study conducted between September 2016 and February 2020. Methods: Patients with relapsing-remitting MS (RRMS) ( Results: In both RRMS and SPMS compared to controls, DCP ( Conclusion: Baseline and change in corneal IC were related to axonal degeneration and treatment status. Evaluation of corneal IC using CCM may allow an assessment of ongoing inflammation, disease progression, and the effect of treatment in MS.

Indexed as

biomarkercorneal confocal microscopyinflammationmultiple sclerosisneurodegeneration

Identifiers

PMID37915502
PMCPMC10617262
OpenAlexW4388097547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.