ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 9 citations in OpenAlex.
- Retinal Vessel Traits and the Development of Balance Impairment: The Canadian Longitudinal Study on Aging.Investigative ophthalmology & visual science · 2026Article
- Multimodal Retinal Imaging for the Detection of Early Alzheimer's Disease: Combining Biochemical, Structural, and Vascular Biomarkers.Bioengineering (Basel, Switzerland) · 2026Article
- Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis.PLOS digital health · 2026Article
- Deep learning retinal imaging model identifies poor brain health among older adults without dementia.Cerebral circulation - cognition and behavior · 2026Article
- Retinal microvascular alterations reflect cerebral small vessel disease burden in frontotemporal dementia: a multimodal OCTA-MRI Study.Alzheimer's research & therapy · 2025Article
- Article
- Review
- Association between retinal microvasculature and cerebral small vessel function in type 2 diabetes: An ultrahigh field MRI study.Diabetes, obesity & metabolism · 2025Article
- The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults.Age and ageing · 2025Article
- Vascular cognitive impairment and dementia: Mechanisms, treatment, and future directions.International journal of stroke : official journal of the International Stroke Society · 2024Review
- Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan.Frontiers in aging · 2024Article
- Automated Retinal Vessel Analysis Based on Fundus Photographs as a Predictor for Non-Ophthalmic Diseases-Evolution and Perspectives.Journal of personalized medicine · 2023Review
- Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Extracerebral microvascular burden links to dementia risk and brain structural changes: Evidence from a large-scale cohort study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: We explored the longitudinal relationship between retinal vascular features and dementia incidence over 10 years. Methods: Among 584 participants from the Three-City-Alienor (3C-Alienor) population-based cohort, quantitative retinal vascular features (caliber, tortuosity, fractal dimension) were measured using semi-automated software. Dementia was actively diagnosed over the follow-up period. Results: One hundred twenty-eight participants (21.9%) developed dementia over a median of 7.1 years. In Cox proportional hazards models adjusted for sociodemographic characteristics, apolipoprotein E ( Discussion: Changes in the retinal microvasculature were associated with dementia risk. More studies are needed to replicate these findings and determine which features might help identify persons at risk at an early stage. HIGHLIGHTS: The retinal microvasculature might reflect the brain microvasculatureWe explored the association between retinal vascular features and incident dementia584 participants from the Three-City-Alienor cohort were followed-up over 10 yearsIncreased arteriolar tortuosity and venular calibers were associated with dementia riskRetinal imaging might help identify persons at risk of future dementia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.