Evidence map›Paper›PMID 37915185›Full record

ArticleDiabetes & metabolism journal2023

Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition.

Ho Gyun Lee, Il Hyeon Jung, Byong Seo Park, Hye Rim Yang, Kwang Kon Kim, Thai Hien Tu, Jung-Yong Yeh, Sewon Lee, Sunggu Yang, Byung Ju Lee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & metabolism journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ho Gyun LeeDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Il Hyeon JungDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Byong Seo ParkDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Hye Rim YangDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Kwang Kon KimDepartment of Biological Science, University of Ulsan, Ulsan, Korea.
Thai Hien TuDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Jung-Yong YehDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Sewon LeeDivision of Sport Science, College of Arts & Physical Education, Incheon National University, Incheon, Korea.
Sunggu YangResearch Center of Brain-Machine Interface, Incheon National University, Incheon, Korea.
Byung Ju LeeDepartment of Biological Science, University of Ulsan, Ulsan, Korea.
Jae Geun KimDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Il Seong Nam-GoongDepartment of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Incheon National University · KRUniversity of Ulsan · KRUlsan College · KR

Funding

Incheon National UniversityMinistry of EducationNational Research Foundation of Korea 2020R1I1A3072427
6 · The paper itself

Abstract

backgruoundSodium-glucose cotransporter 2 (SGLT-2) inhibitors are currently used to treat patients with diabetes. Previous studies have demonstrated that treatment with SGLT-2 inhibitors is accompanied by altered metabolic phenotypes. However, it has not been investigated whether the hypothalamic circuit participates in the development of the compensatory metabolic phenotypes triggered by the treatment with SGLT-2 inhibitors.

methodsMice were fed a standard diet or high-fat diet and treated with dapagliflozin, an SGLT-2 inhibitor. Food intake and energy expenditure were observed using indirect calorimetry system. The activity of hypothalamic neurons in response to dapagliflozin treatment was evaluated by immunohistochemistry with c-Fos antibody. Quantitative real-time polymerase chain reaction was performed to determine gene expression patterns in the hypothalamus of dapagliflozin-treated mice.

resultsDapagliflozin-treated mice displayed enhanced food intake and reduced energy expenditure. Altered neuronal activities were observed in multiple hypothalamic nuclei in association with appetite regulation. Additionally, we found elevated immunosignals of agouti-related peptide neurons in the paraventricular nucleus of the hypothalamus.

conclusionThis study suggests the functional involvement of the hypothalamus in the development of the compensatory metabolic phenotypes induced by SGLT-2 inhibitor treatment.

Indexed as

Sodium-Glucose Transporter 2 InhibitorsAnimalsBenzhydryl CompoundsGlucoseGlucosidesHumansHypothalamusMiceNeuronsPhenotypeSodiumBenzhydryl CompoundsdapagliflozinGlucoseGlucosidesSodiumSodium-Glucose Transporter 2 InhibitorsAppetiteDapagliflozinEnergy metabolismHypothalamusObesity

Identifiers

PMID37915185
PMCPMC10695712
OpenAlexW4386095814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.