ArticleBMC psychiatry2023
Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank.Sexual medicine · 2026Article
- Genetic links between female reproductive milestones and major depressive disorder: evidence from a common genetic factor model.Archives of women's mental health · 2026Article
- Genetic insights into the relationship between age at menarche and mental health-related phenotypes.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- Association Between Maternal Genome-Wide Polygenic Scores for Psychiatric and Neurodevelopmental Disorders and Adverse Perinatal Events: A Danish Population-Based Study.Biological psychiatry global open science · 2026Article
- No causal links between estradiol and female's brain and mental health using Mendelian randomization.Nature communications · 2025Article
- Bidirectional causality between female reproductive traits and temporomandibular disorders.Journal of oral & facial pain and headache · 2025Article
- From Clinic to Mechanisms: Multi-Omics Provide New Insights into Cerebrospinal Fluid Metabolites and the Spectrum of Psychiatric Disorders.Molecular neurobiology · 2025Article
- The association between age at menarche and depression: a cross-sectional analysis of the TABARI cohort at enrollment phase.BMC psychiatry · 2025Article
- MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses.GigaScience · 2025Article
- Investigating the Mediating Role of Mental Disorders in the Relationship Between Early Sexual Intercourse and Intentional Self-Harm: A Two-Step and Multivariable Mendelian Randomization Study.Brain and behavior · 2024Article
- Causal relationship between Women's reproductive traits andFrontiers in genetics · 2024Article
- Health condition and socioeconomic status mediate the causal effect of reproductive traits on nonalcoholic fatty liver disease: evidence from Mendelian randomization study.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe timings of reproductive life events have been examined to be associated with various psychiatric disorders. However, studies have not considered the causal pathways from reproductive behaviors to different psychiatric disorders. This study aimed to investigate the nature of the relationships between five reproductive behaviors and twelve psychiatric disorders.
methodsFirstly, we calculated genetic correlations between reproductive factors and psychiatric disorders. Then two-sample Mendelian randomization (MR) was conducted to estimate the causal associations among five reproductive behaviors, and these reproductive behaviors on twelve psychiatric disorders, using genome-wide association study (GWAS) summary data from genetic consortia. Multivariable MR was then applied to evaluate the direct effect of reproductive behaviors on these psychiatric disorders whilst accounting for other reproductive factors at different life periods.
resultsUnivariable MR analyses provide evidence that age at menarche, age at first sexual intercourse and age at first birth have effects on one (depression), seven (anxiety disorder, ADHD, bipolar disorder, bipolar disorder II, depression, PTSD and schizophrenia) and three psychiatric disorders (ADHD, depression and PTSD) (based on p<7.14×10
conclusionOur findings suggest that reproductive behaviors predominantly exert their detrimental effects on psychiatric disorders and age at first sexual intercourse has direct effects on psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.