Evidence map›Paper›PMID 37914963›Full record

ArticleApplied biochemistry and biotechnology2024

Systemic analysis of the prognostic significance and interaction network of miR-26b-3p in cholangiocarcinoma.

Xijing Yan, Zhongying Hu, Xuejiao Li, Jinliang Liang, Jun Zheng, Jiao Gong, Kunpeng Hu, Xin Sui, Rong Li

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xijing Yan *Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Zhongying Hu *Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Xuejiao Li *Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Jinliang LiangGuangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Jun ZhengDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Jiao GongDepartment of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Kunpeng HuDepartment of Breast and Thyroid Surgery, Lingnan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. hukpeng@mail.sysu.edu.cn.
Xin SuiSurgical ICU, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. drsuixin@126.com.
Rong LiGuangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. Lirong53@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-4951-577X
Sun Yat-sen University · CN

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 202102020237Guangdong Key Laboratory of Liver Disease Research 2020B1212060019Guangzhou Basic and Applied Basic Research Project Co-funded by Municipal Schools (institutes) SL2022A03J01381National Natural Science Foundation of China 81802897National Natural Science Foundation of China 81901943Natural Science Foundation of Guangdong Province 2021A1515011156
6 · The paper itself

Abstract

MicroRNAs (miRNAs) reportedly play significant roles in the progression of various cancers and hold huge potential as both diagnostic tools and therapeutic targets. Given the ongoing uncertainty surrounding the precise functions of several miRNAs in cholangiocarcinoma (CCA), this research undertakes a comprehensive analysis of CCA data sourced from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. The present study identified a novel miRNA, specifically miR-26b-3p, which exhibited prognostic value for individuals with CCA. Notably, miR-26b-3p was upregulated within CCA samples, with an inverse correlation established with patient prognosis (Hazard Ratio = 8.19, p = 0.018). Through a combination of functional enrichment analysis, analysis of the LncRNA-miR-26b-3p-mRNA interaction network, and validation by qRT PCR and western blotting, this study uncovered the potential of miR-26b-3p in potentiating the malignant progression of CCA via regulation of essential genes (including PSMD14, XAB2, SLC4A4) implicated in processes such as endoplasmic reticulum (ER) stress and responses to misfolded proteins. Our findings introduce novel and valuable insights that position miR-26b-3p-associated genes as promising biomarkers for the diagnosis and treatment of CCA.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaMicroRNAsBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMalePrognosisBiomarkers, TumorMicroRNAsMIRN26 microRNA, humanCholangiocarcinomaFunctional enrichment analysisLncRNAs-miR-26b-3p-mRNAs networkMiR-26b-3pPrognostic and diagnostic markers

Identifiers

PMID37914963
OpenAlexW4388231040

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.