ArticleNature2023
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.
Abstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 2 pooled it
22.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 2 syntheses or guidelines pooled it, 183 citations in OpenAlex.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Modelling mitochondrial diseases in neuronsJournal of neuromuscular diseases · 2025Pooled it
- Engineering high-fidelity bone organoids: Operational classification, multilineage crosstalk, biofabrication evidence, and translational validation.Materials today. Bio · 2026Article
- Human-biasedLife science alliance · 2026Article
- Immunoids: Building immunocompetent organoids from human pluripotent stem cells.Cell stem cell · 2026Review
- Immune-stromal interactions at the crossroads of tissue injury, repair, and tumor progression.Med (New York, N.Y.) · 2026Review
- Macrophage heterogeneity in human secondary lymphoid organs.Clinical science (London, England : 1979) · 2026Review
- Beyond phenotypic markers: rethinking dopaminergic identity in iPSC-derived neurons.Cell communication and signaling : CCS · 2026Review
- A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.Nature neuroscience · 2026Article
- Antigen presentation by CD40Nature · 2026Article
- Glial Cell Niche Induces Astrocytic Differentiation of NSCs via the BMP4-Smad1/5/8 Signaling Pathway.International journal of molecular sciences · 2026Article
- [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Patient-derived resources for decoding and targeting brain metastases ecosystems.EMBO molecular medicine · 2026Review
- Harnessing intermediate-scale bioreactors for next-generation macrophage production and application.Nature protocols · 2026Review
- Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine.Protein & cell · 2026Review
- Cholesterol Drives IFITM3CNS neuroscience & therapeutics · 2026Article
- Corticosterone-linked microglial activity underpins sexually dimorphic neuroplasticity after ketamine anesthesia.Science advances · 2026Article
- Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic.Neural regeneration research · 2026Article
- Generating Microglia-Integrated Cortical Organoids from Human Embryonic Stem Cells.Stem cell reviews and reports · 2026Article
- Brain organoids and genome editing: A new era in understanding human brain development and disorders.Neural regeneration research · 2026Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
61 authors at 9 institutions in 6 countries.
Dong Shin Park *Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Tatsuya Kozaki *Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Satish Kumar TiwariSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Marco MoreiraINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
Ahad KhalilnezhadSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Federico TortaDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Nicolas OliviéInstitut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0002-0437-3846
Chung Hwee ThiamDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Oniko LianiSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Aymeric SilvinSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0003-2748-8555
Wint Wint PhooFunctional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.
Liang GaoDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Alexander TrieblDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Wai Kin ThamSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.
Leticia GonçalvesINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.ORCID 0009-0004-8717-9011
Wan Ting KongSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-9271-841X
Sethi RamanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Xiao Meng ZhangSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Garett DunsmoreINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
Charles Antoine DutertreSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0001-7950-3652
Salanne LeeSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Jia Min OngSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Akhila BalachanderSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-2168-0063
Shabnam KhalilnezhadSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Josephine LumSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0003-1108-5989
Kaibo DuanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0003-0523-8993
Ze Ming LimSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Leonard TanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Ivy LowSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Kagistia Hana UtamiTranslational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research, Singapore, Singapore.
Xin Yi YeoInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore, Singapore.
Sylvaine Di TommasoOncoprot Platform, TBM-Core US 005, Bordeaux, France.
Jean-William DupuyBordeaux Protéome, University of Bordeaux, Bordeaux, France.ORCID 0000-0002-2448-4797
Balazs VargaWellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4005-1203
Ragnhildur Thora KaradottirWellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9675-2722
Mufeeda Changaramvally MadathummalA*STAR Microscopy Platform Electron Microscopy, Research Support Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Isabelle BonneDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-8261-6794
Benoit MalleretSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0001-9658-7528
Zainab Yasin BinteSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Ngan Wei DaSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Yingrou TanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Wei Jie WongShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jinqiu ZhangTranslational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research, Singapore, Singapore.
Jinmiao ChenSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0001-7547-6423
Radoslaw M SobotaFunctional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-2455-2526
Shanshan W HowlandSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0003-4794-1564
Lai Guan NgSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0003-1905-3586
Frédéric SaltelOncoprot Platform, TBM-Core US 005, Bordeaux, France.
David CastelINSERM U981, Molecular Predictors and New Targets in Oncology & Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-0247-080X
Jacques GrillINSERM U981, Molecular Predictors and New Targets in Oncology & Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-4773-3001
Veronique MinardINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
Salvatore AlbaniTranslational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.ORCID 0000-0002-5602-6256
Jerry K Y ChanDepartment of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
Morgane Sonia ThionInstitut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0003-2364-8451
Sang Yong JungInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore, Singapore.
Markus R WenkDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mahmoud A PouladiTranslational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research, Singapore, Singapore.
Claudia PasqualiniINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
Veronique AngeliDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-2759-3497
Olivier N F CexusSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore. florent_ginhoux@immunol.a-star.edu.sg.ORCID 0000-0002-2857-7755
Agency for Science, Technology and Research · SGInserm · FRNational University of Singapore · SGCentre National de la Recherche Scientifique · FRWellcome/MRC Cambridge Stem Cell Institute · GBKK Women's and Children's Hospital · SGShanghai Jiao Tong University · CNSingHealth Duke-NUS Academic Medical Centre · SGUniversité de Bordeaux · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia are specialized brain-resident macrophages that arise from primitive macrophages colonizing the embryonic brain
Indexed as
BrainCholesterolInduced Pluripotent Stem CellsMicrogliaNeural Stem CellsNeurogenesisOrganoidsAnimalsAxonsCell DifferentiationCell ProliferationEstersHumansLipid DropletsMicePerilipin-2CholesterolEstersPerilipin-2PLIN2 protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.