Evidence map›Paper›PMID 37914936›Full record

ArticleNature2023

Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.

Shabareesh Pidathala, Shuyun Liao, Yaxin Dai, Xiao Li, Changkun Long, Chi-Lun Chang, Zhe Zhang, Chia-Hsueh Lee

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Multitype hand writing as a digital marker for Parkinson's disease.Clinical parkinsonism & related disorders · 2026
    Article
  7. Structural basis of G6P/Pi transport and inhibition in SLC37A4.Nature structural & molecular biology · 2026
    Article
  8. Article
  9. Article
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  11. Article
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  13. Article
  14. Article
  15. Article
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  17. Article
  18. Review
  19. Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Shabareesh Pidathala *Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shuyun Liao *State Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing, China.
Yaxin Dai *Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xiao LiDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-4187-1430
Changkun LongState Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing, China.ORCID 0000-0002-6474-7627
Chi-Lun ChangDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0017-2243
Zhe ZhangState Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing, China. zzhang01@pku.edu.cn.ORCID 0000-0002-4932-4343
Chia-Hsueh LeeDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. chiahsueh.lee@stjude.org.ORCID 0000-0003-0819-6477
St. Jude Children's Research Hospital · USPeking University · CN

Funding

Structural and Functional Studies of Human Serine Palmitoyltransferase ComplexesR01GM143282 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LEE, CHIA-HSUEH · 2021 to 2025
$1.8M
Structural and functional investigations on synaptic vesicular transportersR01NS133147 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Chia-Hsueh Lee · 2024 to 2026
$1.6M
NIGMS NIH HHS R01 GM143282NINDS NIH HHS R01 NS133147
6 · The paper itself

Abstract

Monoamine neurotransmitters such as dopamine and serotonin control important brain pathways, including movement, sleep, reward and mood

Indexed as

Neurotransmitter AgentsReserpineSerotoninTetrabenazineVesicular Monoamine Transport ProteinsAdrenergic Uptake InhibitorsBiological TransportCryoelectron MicroscopyHumansSubstrate SpecificitySynaptic TransmissionAdrenergic Uptake InhibitorsNeurotransmitter AgentsReserpineSerotoninSLC18A2 protein, humanTetrabenazineVesicular Monoamine Transport Proteins

Identifiers

PMID37914936
PMCPMC12832108
OpenAlexW4388126737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.