ArticleNature2023
Mouse genome rewriting and tailoring of three important disease loci.
Open access · hybridAbstract read
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 39 citations in OpenAlex.
- CRISPR-mediated precise large fragment insertion in zygotes enables rapid generation of humanized immunoglobulin heavy-chain mice.Immunity · 2026Article
- Synthetic Regulatory Genomics.Annual review of genomics and human genetics · 2026Review
- BxbI-mediated insertion of a 77kb human RET sensitive haplotype into the mouse genome to generate a humanized model of Hirschsprung disease.bioRxiv : the preprint server for biology · 2026Article
- Synthetic rewriting of the IGH locus.Cell genomics · 2026Article
- Improved vector toolkit for genome writing in mammalian cells.bioRxiv : the preprint server for biology · 2026Article
- Programmable nanobody circuits for cell selection.bioRxiv : the preprint server for biology · 2026Article
- Review
- A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci.Nature communications · 2026Article
- Synthetic rewriting technologies in mammalian cells.Nature communications · 2026Review
- Genome writing and Targeted Delivery of thebioRxiv : the preprint server for biology · 2026Article
- Synthetic biology and genome engineering in support of human, agricultural, and environmental security.Frontiers in bioengineering and biotechnology · 2026Article
- Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems.Cell systems · 2025Review
- A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording.Nature biotechnology · 2025Article
- Iterative improvement of deep learning models using synthetic regulatory genomics.Genome research · 2025Article
- Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism.bioRxiv : the preprint server for biology · 2025Article
- Human Genome REWRITE for Off-the-Shelf Stem Cells Reveals an "Epigenetic Ghost".bioRxiv : the preprint server for biology · 2025Article
- Evolving a bat wing by reusing an existing gene program.Nature ecology & evolution · 2025Article
- The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes.Annual review of genomics and human genetics · 2025Review
- De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos.Nature methods · 2025Article
- The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 2 institutions in 2 countries.
Weimin ZhangInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-8836-1438
Ilona GolynkerDepartment of Microbiology, NYU Langone Health, New York, NY, USA.
Ran BroshInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-9714-8623
Alvaro FajardoDepartment of Microbiology, NYU Langone Health, New York, NY, USA.
Yinan ZhuInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Aleksandra M WudzinskaInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-3143-7673
Raquel OrdoñezInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-6924-5175
André M Ribeiro-Dos-SantosInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Lucia CarrauDepartment of Microbiology, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-0260-2841
Payal Damani-YokotaDepartment of Microbiology, NYU Langone Health, New York, NY, USA.
Stephen T YeungDepartment of Microbiology, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-9710-5567
Camille KhairallahDepartment of Microbiology, NYU Langone Health, New York, NY, USA.
Antonio Vela GartnerInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Noor ChalhoubInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Emily HuangInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Hannah J AsheInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Kamal M KhannaDepartment of Microbiology, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-9328-3817
Matthew T MauranoInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-2218-8628
Sang Yong KimDepartment of Pathology, NYU Langone Health, New York, NY, USA.
Benjamin R tenOeverDepartment of Microbiology, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-0324-3078
Jef D BoekeInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA. jef.boeke@nyulangone.org.ORCID 0000-0001-5322-4946
Institute for Systems Biology · USNYU Langone Health · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aristotelis Tsirigos · 1985 to 2026
$83.1MSupplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9MNovel lung resident interstitial macrophage subset with distinct localization and polarizationR01AI143861 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KHANNA, KAMAL MOHAN · 2019 to 2023
$3.3MLung resident macrophage subsets in regulating tissue immunity - Resubmission - 1F32HL154598 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DAMANI-YOKOTA, PAYAL · 2021 to 2022
$85kNCI NIH HHS P30 CA016087NHGRI NIH HHS RM1 HG009491NHLBI NIH HHS F32 HL154598NIAID NIH HHS R01 AI143861
Abstract
Genetically engineered mouse models (GEMMs) help us to understand human pathologies and develop new therapies, yet faithfully recapitulating human diseases in mice is challenging. Advances in genomics have highlighted the importance of non-coding regulatory genome sequences, which control spatiotemporal gene expression patterns and splicing in many human diseases
Indexed as
Angiotensin-Converting Enzyme 2COVID-19Disease Models, AnimalGenetic EngineeringGenomeTumor Suppressor Protein p53AllelesAnimalsDNADrug Resistance, MicrobialHumansMiceMouse Embryonic Stem CellsSARS-CoV-2Serine EndopeptidasesACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2DNASerine EndopeptidasesTMPRSS2 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.