ArticleScientific reports2023
Structure-yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Design, Synthesis, and In Vitro Evaluation of Pinostrobin-Based Hydrazones as Potent α‑Glucosidase Inhibitors.ACS omega · 2026Article
- Novel sulfonylhydrazide anacardic acid derivatives as potent α-glucosidase inhibitors: Synthesis, crystal structure, biological evaluation, and computational studies.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Six Bioactive Small Molecules fromFoods (Basel, Switzerland) · 2026Article
- Exploring the α-Glucosidase Inhibitory Activity of Bioactive Compounds fromInternational journal of molecular sciences · 2026Article
- An updated overview of alkaloids for the prevention and treatment of metabolic dysfunction-associated steatotic liver disease.Frontiers in pharmacology · 2026Review
- Identification of Sulfonamide-Vinyl Sulfone/Chalcone and Berberine-Cinnamic Acid Hybrids as Potent DENV and ZIKV NS2B/NS3 Allosteric Inhibitors.International journal of molecular sciences · 2025Article
- Inhibitory Effect ofInternational journal of molecular sciences · 2025Article
- Chiral pyrimidinyl-piperazine carboxamide derivatives as potent yeast α-glucosidase inhibitors.Scientific reports · 2025Article
- Article
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9 authors.
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Abstract
Thirty-five 9-O-berberrubine carboxylate derivatives were synthesized and evaluated for yeast α-glucosidase inhibitory activity. All compounds demonstrated better inhibitory activities than the parent compounds berberine (BBR) and berberrubine (BBRB), and a positive control, acarbose. The structure-activity correlation study indicated that most of the substituents on the benzoate moiety such as methoxy, hydroxy, methylenedioxy, benzyloxy, halogen, trifluoromethyl, nitro and alkyl can contribute to the activities except multi-methoxy, fluoro and cyano. In addition, replacing benzoate with naphthoate, cinnamate, piperate or diphenylacetate also led to an increase in inhibitory activities except with phenyl acetate. 9, 26, 27, 28 and 33 exhibited the most potent α-glucosidase inhibitory activities with the IC
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