ArticleNature communications2023
Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Comparative Physiological and Metabolomic Responses ofAnimals : an open access journal from MDPI · 2026Article
- Research progress on flavonoid-mediated communication between plants and rhizosphere microorganisms.Archives of microbiology · 2026Review
- Metabolomic analysis reveals flavonoid accumulation patterns in four apricot cultivars.Food chemistry: X · 2026Article
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- Discovery of an isoflavone biosynthetic pathway in Iridaceae plants.Nature communications · 2026Article
- The BAHD acyltransferase STBR1 confers both saline-alkali tolerance and blast resistance by stabilizing the non-canonical catalase CATA to promote HPlant communications · 2026Article
- Integrated genome-wide association study (GWAS) and metabolomics identify genetic and metabolic drivers of stripe rust resistance in wheat from the Western Himalayas.Functional & integrative genomics · 2026Article
- Metabolic engineering inaBIOTECH · 2025Review
- Metabolome-driven microbiome assembly in ginger (Zingiber officinale) enhances nutrient cycling and crop yield through keystone taxa.Communications biology · 2025Article
- Synthetic Polyploidisation Enhances Fusarium graminearum Tolerance in Wheat by Reshaping the Transcriptome and Strengthening the Microbiome.Plant biotechnology journal · 2025Article
- Transcriptome analysis reveals key pathways and regulatory networks involved in soybean's early resistance to Peronospora manshurica.BMC plant biology · 2025Article
- Unveiling the root-rhizosphere environment of perennial wheat: a metabolomic perspective.BMC plant biology · 2025Article
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Advances in synthesizing plant-derived isoflavones and their precursors with multiple pharmacological activities using engineered yeasts.Microbial cell factories · 2025Review
- Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium.PLoS pathogens · 2025Article
- Review
- Review on antibacterial flavonoids from genusHeliyon · 2025Review
- Screening of soybean antifungal isoflavones based on targeted metabolomics analysis.Food chemistry: X · 2025Article
- Evolution of plant metabolism: the state-of-the-art.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
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Authors and funding
13 authors at 1 institution in 4 countries.
Funding
Abstract
Isoflavones are a group of phenolic compounds mostly restricted to plants of the legume family, where they mediate important interactions with plant-associated microbes, including in defense from pathogens and in nodulation. Their well-studied health promoting attributes have made them a prime target for metabolic engineering, both for bioproduction of isoflavones as high-value molecules, and in biofortification of food crops. A key gene in their biosynthesis, isoflavone synthase, was identified in legumes over two decades ago, but little is known about formation of isoflavones outside of this family. Here we identify a specialized wheat-specific isoflavone synthase, TaCYP71F53, which catalyzes a different reaction from the leguminous isoflavone synthases, thus revealing an alternative path to isoflavonoid biosynthesis and providing a non-transgenic route for engineering isoflavone production in wheat. TaCYP71F53 forms part of a biosynthetic gene cluster that produces a naringenin-derived O-methylated isoflavone, 5-hydroxy-2',4',7-trimethoxyisoflavone, triticein. Pathogen-induced production and in vitro antimicrobial activity of triticein suggest a defense-related role for this molecule in wheat. Genomic and metabolic analyses of wheat ancestral grasses further show that the triticein gene cluster was introduced into domesticated emmer wheat through natural hybridization ~9000 years ago, and encodes a pathogen-responsive metabolic pathway that is conserved in modern bread wheat varieties.
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